Results 81 to 90 of about 14,345,300 (303)
Liquid information flow control
Proceedings of the ACM on Programming Languages, 2020 We present Lifty, a domain-specific language for data-centric applications that manipulate sensitive data. A Lifty programmer annotates the sources of sensitive data with declarative security policies, and the language statically and automatically verifies that the application handles the data according to the policies. Moreover, if verification fails,
Nadia Polikarpova +5 more
openaire +5 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Application of High-Speed Self-Aligned Focusing Schlieren System for Supersonic Flow Velocimetry
AerospaceA self-aligned focusing schlieren (SAFS) system combines the field of view of a conventional schlieren system with the defocus blur of a focusing schlieren system away from the object plane.
Philip A. Lax, Sergey B. Leonov
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Applied SciencesTraditional elastic correction methods fail to address the significant aeroelastic interactions arising from unsteady flow fields and structural deformations during aggressive maneuvers.
Shuang Chen, Pengzhen He, Shuling Tian
doaj +1 more source
A control-theoretic approach to flow control [PDF]
Proceedings of the conference on Communications architecture & protocols, 1991 This paper presents a control-theoretic approach to reactive flow control in networks that do not reserve bandwidth. We assume a round-robin-like queue service discipline in the output queues of the network's switches, and propose deterministic and stochastic models for a single conversation in a network of such switches.
openaire +2 more sources
Active Flow Separation Control on a High-Lift Wing-Body Configuration - Part 1: Baseline Flow and Constant Blowing [PDF]
, 2011 This paper describes the influence of grid resolution and turbulence modeling for a 3D transport aircraft in high lift configuration with massive flap separation.
Breitenstein, Wiebke +4 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source