Results 71 to 80 of about 14,345,300 (303)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Periodic transonic flow and control [PDF]

, 2008
The current understanding of periodic transonic flow is reviewed briefly. The effects of boundary-layer transition, non-adiabatic wall conditions and modifications to the aerofoil surface geometry at the shock interactions on periodic transonic flow are ...
Quest, J., Early, J.M., Tulita, C., C. Tulita, Raghunathan, Srinivasan, Benard, Emmanuel, Raghunathan, S., Quest, Juergen, E. Benard, S. Raghunathan, Benard, E., Tulita, Catalin, J. Quest, Early, Juliana M., J.M. Early   +14 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Capacity Testing and Local Flow Analysis of a Geometrically Complex Trim Installed within a Commercial Control Valve [PDF]

Industrial control valves often handle flows with very high pressure drops (conditions often referred to as severe service). In order to cope with such pressure drops, geometrically complex valve trims with many stages of pressure drops, are designed to ...
Rakesh, Mishra, Taimoor, Asim, Carlos, Oliveira, Matthew, Charlton   +3 more
core   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Effect of forward-facing concavity on the aerodynamic and aerothermodynamic characteristics of an atmospheric Re-entry vehicle

Results in Engineering
Aerodynamic heating and drag remain the two foremost factors to consider in the design of a re-entry vehicle. Mitigating the aero-heating effects is paramount for re-entry vehicles decelerating higher up in the atmosphere at hypersonic speeds.
Khalid A. Juhany, Anirudh Renganathan, Rohit S. Varma, Karthik Vel E, Amjad Ali Pasha, D. Siva Krishna Reddy, Seraj Alzhrani, S. Nadaraja Pillai   +7 more
doaj   +1 more source

Flow for Meta Control

CoRR, 2014
The psychological state of flow has been linked to optimizing human performance. A key condition of flow emergence is a match between the human abilities and complexity of the task. We propose a simple computational model of flow for Artificial Intelligence (AI) agents.
openaire   +2 more sources

Turbulent structures, integral length scale and turbulent kinetic energy (TKE) dissipation rate in compound channel flow [PDF]

, 2017
In the present study, high data rate measurements were obtained for the streamwise and vertical velocity components using 2D Laser Doppler Velocimeter. The turbulent field in a straight compound-channel flow was characterized for three different uniform ...
Roja-Solórzano, Luís R., Bento Leal, João, Ricardo, Azevedo, Azevedo, Ricardo   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source