Results 111 to 120 of about 6,040,269 (294)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Flow Measurement Model of Ultrasonic Flowmeter for Gas-Liquid Two-Phase Stratified and Annular Flows

Advances in Mechanical Engineering, 2014
An error correction model for ultrasonic gas flowmeter was proposed to explore the potential of an ultrasonic flowmeter for metering gas-liquid stratified and annular flows.
Lanchang Xing, Chenquan Hua, Hao Zhu, Wolfgang Drahm   +3 more
doaj   +1 more source

Fluid flow restrictor Patent [PDF]

, 1970
Tubular flow restrictor for gas flow control in ...
Bastien, G. J.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Study of the active flow control of an airfoil [PDF]

, 2019
The student will use a CFD code for simulating the turbulent flow around an airfoil with and without active flow control. The student should have to get familiar with the code and run several cases in order to analyse the influence of different ...
Cuesta Simón, Carlos
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Stable Droplet Manipulation in Multiple Directions on a Magnetically Responsive Micropillar Array Surface

Advanced Materials Interfaces
Droplets constitute an essential discrete form of liquids and are prevalent in both natural and industrial fields. Droplet manipulation technologies have broad application prospects in various fields, including biomedical devices, chemical engineering ...
Xinyuan Liu, Li Jia, Yi Ding, Chao Dang, Liaofei Yin, Jinzhu Xu, Ruiqi Zhang   +6 more
doaj   +1 more source

Plasma-based Control of Supersonic Nozzle Flow

, 2009
The flow structure obtained when Localized Arc Filament Plasma Actuators (LAFPA) are employed to control the flow issuing from a perfectly expanded Mach 1.3 nozzle is elucidated by visualizing coherent structures obtained from Implicit Large-Eddy ...
Gaitonde, Datta V.
core  

Information Flow Model for Commercial Security [PDF]

, 2009
Information flow in Discretionary Access Control (DAC) is a well-known difficult problem. This paper formalizes the fundamental concepts and establishes a theory of information flow security.
Pan, Jene
core   +1 more source