Results 191 to 200 of about 20,769,954 (368)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Passive flow control via tip grooving and stall fencing mechanisms of a marine energy harvesting turbine. [PDF]

Sci Rep, 2023
Das TK, Islam N, Samad A, Pasha AA.
europepmc   +1 more source

Effects Of Low Molecular Weight Dextran On Peripheral Blood Flow With Controlled Cardiac Output

, 1967
James W. Kilman, John A. Waldhausen, Harris B. Shumacker   +2 more
openalex   +2 more sources

Blood Flow, Oxygen Consumption, and Free Fatty Acid Release in Subcutaneous Adipose Tissue during Hemorrhagic Shock in Control and Phenoxybenzamine-Treated Dogs [PDF]

, 1970
Amanda Kovach, Sune Rosell, Péter Sándor, Edith Koltay, E Kovách, NATÁLIA TOMKA   +5 more
openalex   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Rapid ventricular overdrive pacing and other advanced flow-control techniques for the endovascular embolization of vein of galen malformations. [PDF]

Front Pediatr, 2023
Baranoski JF, Catapano JS, Albuquerque FC, Abruzzo TA.   +3 more
europepmc   +1 more source

Cortical blood flow in controlled hypotension as measured by thermal diffusion [PDF]

, 1973
L. P. Carter, J Atkinson
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

CNN-based flow control device modelling on aerodynamic airfoils. [PDF]

Sci Rep, 2022
Portal-Porras K, Fernandez-Gamiz U, Zulueta E, Ballesteros-Coll A, Zulueta A.   +4 more
europepmc   +1 more source

Non-interacting Control of Pressurised Flow Boxes

, 1969
R. E. Johnston
openalex   +1 more source