Results 61 to 70 of about 20,769,954 (368)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Interaction of the Shock Train Leading Edge and Filamentary Plasma in a Supersonic Duct
FluidsQuasi-direct current (Q-DC) filamentary electrical discharges are used to control the shock train in a back-pressured Mach 2 duct flow. The coupled interaction between the plasma filaments and the shock train leading edge (STLE) is studied for a variety ...
Loren C. Hahn +3 more
doaj +1 more source
Compositional Separation of Control Flow and Data Flow [PDF]
arXiv, 2023 Every Model of High-Level Computation (MHC) has an underlying composition mechanism for combining simple computation devices into more complex ones. Composition can be done by (explicitly or implicitly) defining control flow, data flow or any combination thereof.
arxiv
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Investigation of thrust vector angle control law based on micro-turbojet engine
AIP Advances, 2022 The fluid thrust vectoring nozzle has a fixed profile, few moving parts, and lightweight structure, providing effective flight control for high maneuvering aircraft. The nonlinear control law of the jet deflection angle is one of the critical problems of
Shaoqing Chi +3 more
doaj +1 more source
Flow control with rotating cylinders
Journal of Fluid Mechanics, 2017 We study the use of small counter-rotating cylinders to control the streaming flow past a larger main cylinder for drag reduction. In a water tunnel experiment at a Reynolds number of 47 000 with a three-dimensional and turbulent wake, particle image ...
James Schulmeister +3 more
semanticscholar +1 more source
Circadian control of brain glymphatic and lymphatic fluid flow
Nature Communications, 2020 The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste.
L. Hablitz +8 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Experimental and numerical investigation of flow over spiral grooved cylinders
Advances in Mechanical Engineering, 2022 This study experimentally and numerically investigates the performance of a circular cylinder with a spiral grooved surface in terms of reducing wind drag.
Jun Zhang +4 more
doaj +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source