Results 101 to 110 of about 5,519,742 (398)
Leukemia stem cells in acute myeloid leukemia-mimicking “space and time continuum”?
HaematologicaNot available.
Adriana Plesa, Christophe Roumier
doaj +1 more source
Human Bone Marrow Assessment by Single Cell RNA Sequencing, Mass Cytometry and Flow Cytometry
bioRxiv, 2018 New techniques for single-cell analysis have led to insights into hematopoiesis and the immune system, but the ability of these techniques to cross-validate and reproducibly identify the biological variation in diverse human samples is currently unproven.
K. Oetjen +8 more
semanticscholar +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells. [PDF]
, 2019 Selective differentiation of naive T cells into multipotent T cells is of great interest clinically for the generation of cell-based cancer immunotherapies. Cellular differentiation depends crucially on division state and time.
Bendall, Sean C +7 more
core
Best Practices for Preparing a Single Cell Suspension from Solid Tissues for Flow Cytometry
Cytometry Part A, 2018 Preparing a single cell suspension is a critical step in any solid tissue flow cytometry experiment. Tissue dissection, enzymatic digestion, and mechanical dissociation are three significant steps leading to the degradation of the extracellular matrix ...
A. Reichard, K. Asosingh
semanticscholar +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Differential leukocyte count method for bovine low somatic cell count milk [PDF]
, 2003 Whereas many differential leukocyte count methods for high somatic cell count (SCC) milk from mastitic cows are available, only a few have been developed for low SCC milk.
Burvenich, Christian +4 more
core +2 more sources
The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome
Frontiers in Immunology, 2019 Sepsis remains a major challenge in translational research given its heterogeneous pathophysiology and the lack of specific therapeutics. The use of humanized mouse chimeras with transplanted human hematopoietic cells may improve the clinical relevance ...
Tomasz Skirecki +7 more
doaj +1 more source
Combination of Flow Cytometry and Functional Imaging for Monitoring of Residual Disease in Myeloma
Leukemia, 2018 The iliac crest is the sampling site for minimal residual disease (MRD) monitoring in multiple myeloma (MM). However, the disease distribution is often heterogeneous, and imaging can be used to complement MRD detection at a single site.
L. Rasche +21 more
semanticscholar +1 more source