Results 81 to 90 of about 799,277 (314)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Automation in high-content flow cytometry screening [PDF]

, 2009
High-content flow cytometric screening (FC-HCS) is a 21st Century technology that combines robotic fluid handling, flow cytometric instrumentation, and bioinformatics software, so that relatively large numbers of flow cytometric samples can be processed ...
M. P. Wand, Wand, MP, U. Naumann, Naumann, U   +3 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Impact of high-sensitivity flow cytometry on peri-transplant minimal residual disease kinetics in acute leukemia

Scientific Reports
Minimal residual disease (MRD) detected before hematopoietic cell transplantation (HCT) is associated with adverse outcomes in patients with high-risk acute leukemia.
Ana Paula de Azambuja, Miriam Perlingeiro Beltrame, Mariester Malvezzi, Yara Carolina Schluga, Julie Lillian Pimentel Justus, Alberto Cardoso Martins Lima, Vaneuza Araujo Moreira Funke, Carmem Bonfim, Ricardo Pasquini   +8 more
doaj   +1 more source

Detection of mycoplasmas in goat milk by flow cytometry [PDF]

, 2007
The detection of mycoplasma in milk can be performed by either culture techniques or polymerase chain reaction (PCR) based methods. Although PCR can reduce the average diagnostic time to 5 h in comparison with the several days for the isolation of the ...
Assunção, Patricia, Carlos M. Ruiz de Galarreta, De La Fe, Christian, Antunes, Nuno T., Davey, Hazel M., Rosales, Ruben S., Jose B. Poveda, Nuno T. Antunes, Ramirez, Ana S., Ruben S. Rosales, Hazel M. Davey, Poveda, Jose B., Ruiz De Galarreta, Carlos M., Ana S. Ramirez, Christian de la Fe, Patricia Assunção   +15 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Flow Cytometry as the Tool to Define Peripheral Blood Leukocyte Signatures in Acute EBV Infection

Cells
Primary Epstein–Barr virus (EBV) infection which can manifest as infectious mononucleosis (IM) is commonly acquired during childhood. EBV primarily invades B cells leading to a lytic reaction; the control of the infection is handled by natural killer and
Pragya Singh, Manisha Gadgeel, Batool AlQanber, Ahmad Farooqi, Süreyya Savaşan   +4 more
doaj   +1 more source

No Mutation Detected in Five Hot Spot Codons of the Tp53 Gene by Restriction Site Mutation Analysis in Patients with Carcinoma of the Tongue

The International Journal of Biological Markers, 2010
The present study evaluated 5 of the 8 main TP53 mutation hot spots in cancer by restriction site mutation analysis and compared the results with p53 protein expression in patients with cancer of the tongue.
Hemangini H. Vora, Shalvi V. Mehta, Shilin N. Shukla, Pankaj M. Shah   +3 more
doaj   +1 more source

Flow Cytometry [PDF]

Journal of Investigative Dermatology, 2012
Jahan-Tigh, Richard R., Ryan, Caitriona, Obermoser, Gerlinde, Schwarzenberger, Kathryn   +3 more
openaire   +2 more sources

Flow cytometry of keratinocytes [PDF]

Journal of Cutaneous Pathology, 1983
A prerequisite for using flow cytometry (FCM) is the availability of isolated single cells. Procedures for separation and isolation of keratinocytes from animals and man are available, and the resulting single cell suspensions have been subjected to FCM measurements.
openaire   +2 more sources