Results 61 to 70 of about 799,277 (314)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Analyzing the involvement of diverse cell death-related genes in diffuse large B-cell lymphoma using bioinformatics techniques

Heliyon
Diffuse large B-cell lymphoma (DLBCL) stands as the most prevalent subtype of non-Hodgkin's lymphoma and exhibits significant heterogeneity. Various forms of programmed cell death (PCD) have been established to have close associations with tumor onset ...
Heyuan Feng, Xiyuan Zhang, Jian Kang
doaj   +1 more source

Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia

BMC Research Notes, 2018
Objective The objective of this study was to evaluate the cluster of differentiation-38 (CD38) expression in Sudanese patients with chronic lymphocytic leukemia (CLL) and to determine its association with clinical and laboratory characteristics of the ...
Enaam Abdelrhman Abdelgader, Nada Hassan Eltayeb, Tasniem Ahmed Eltahir, Osama Ali Altayeb, Eman Abbass Fadul, Eldirdiri M. Abdel Rahman, Tarig H. Merghani   +6 more
doaj   +1 more source

Discriminating bacterial phenotypes at the population and single‐cell level : a comparison of flow cytometry and Raman spectroscopy fingerprinting [PDF]

, 2020
Investigating phenotypic heterogeneity can help to better understand and manage microbial communities. However, characterizing phenotypic heterogeneity remains a challenge, as there is no standardized analysis framework.
Props, RubenLA250001103451768020019437730000-0003-4996-25963D46D458-F0EE-11E1-A9DE-61C894A0A6B4, García Timermans, CristinaUGent0001512186538020022035529792841549360000-0002-7052-1616B9D8003C-6BAC-11E5-AB7C-B566B5D1D7B1, Waegeman, WillemLA260020000353208010018524540000-0002-5950-3003F71947FE-F0ED-11E1-A9DE-61C894A0A6B4, Skirtach, AndreLA250001108599838020010457170000-0002-4468-76203AEA5496-F0EE-11E1-A9DE-61C894A0A6B4, Heyse, JasmineUGent00012053310980200270613497156118438120468E0E-F59C-11E1-8C35-769E10BDE39D, Rubbens, Peter0000801888868020021466659712079831330000-0001-5595-475810C81B08-F0EE-11E1-A9DE-61C894A0A6B4, Kerckhof, Frederiek-MaartenLA250000605446698020010391480000-0002-4472-6810027E6D9A-F0EE-11E1-A9DE-61C894A0A6B4, Boon, NicoLA258010012274120000-0002-7734-3103F56DD06E-F0ED-11E1-A9DE-61C894A0A6B4   +7 more
core  

Visualization of cell composition and maturation in the bone marrow using 10-color flow cytometry and radar plots [PDF]

, 2017
Background: The enormous potential of complex data files generated by 10-color flow cytometry (FC) is hindered by the requirement for exhaustive manual gating and the complexity of multidimensional data visualization. We propose a model using radar plots
Rajab, Amr,, Katayoon Jafari, Jafari, Katayoon, Tierens, Anne M.,, Schuh, André,, Rumina Musani, Jafari, Katayoon,, Porwit, Anna,, Musani, Rumina, Amr Rajab, André Schuh, Rajab, Amr, Porwit, Anna, Anna Porwit, Schuh, André, Tierens, Anne M., Anne Tierens, Lund University., Musani, Rumina,   +18 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bi-lineage acute leukemia; a case with B-lymphoblasts and myeloid blasts [PDF]

Journal of Preventive Epidemiology, 2019
Mixed phenotypic acute leukemia (MPAL) is classified under acute leukemia of ambiguous lineage. Most reported cases of acute ambiguous leukemia belong to bi-phenotypic leukemia. However, bi-lineage leukemia is rare.
Esmaeil Shahabi Satlsar, Farahnaz Ghahremanfard, Anahid Nabavi, Mohammad Moslehabadi Farahani   +3 more
doaj  

Image cytometric DNA analysis in human breast cancer analysis may add prognostic information in diploid cases with low S-phase fraction by flow cytometry [PDF]

, 1992
Measurements of DNA ploidy can be performed either with image cytometry (ICM) or flow cytometry (FCM); both methods provide independent prognostic information in primary breast cancer.
Helgi Sigurdsson, Olsson, Håkan,, Ghita Fallenius‐Vecchi, Håkan Olsson, Sigurdsson, Helgi, Baldetorp, Bo, Dick Killander, Fernö, Mårten,, Fernö, Mårten, Fallenius-Vecchi, Ghita, Anders Fallenius, Bo Baldetorp, Åkerman, Måns,, Idvall, Inger, Killander, Dick, Fallenius, Anders, Ingrid Idvall, Åkerman, Måns, Mårten Fernö, Killander, Dick,, Lund University., Olsson, Håkan, Baldetorp, Bo,, Måns Åkerman   +23 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A rapid and reliable method of counting neurons and other cells in brain tissue: a comparison of flow cytometry and manual counting methods

Frontiers in Neuroanatomy, 2010
It is of critical importance to understand the numbers and distributions of neurons and non-neurons in the cerebral cortex because cell numbers are reduced with normal aging and by diseases of the CNS.
Christine E Collins, Nicole A Young, David K Flaherty, David C Airey, Jon H Kaas   +4 more
doaj   +1 more source