Results 41 to 50 of about 3,125,910 (203)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Seven-year study of viability and absolute counts in cord blood units by flow cytometry in Greece

International Journal of Hematology-Oncology and Stem Cell Research, 2015
#No Abstract#
Vasiliki E-Kalodimou, Irene Mitrou, Antonio Vlachousis   +2 more
doaj  

Unravelling Plasma Extracellular Vesicle Diversity With Optimised Spectral Flow Cytometry

Journal of Extracellular Biology
Extracellular vesicles (EVs) are crucial for intercellular communication and are found in various biological fluids. The identification and immunophenotyping of such small particles continue to pose significant challenges.
Daniela Boselli, Francesca Clemente, Simona Di Terlizzi, Christina Pagiatakis, Laura Papa, Genny Del Zotto, Chiara Villa, Giuseppe Alvise Ramirez, Norma Maugeri, Angelo A. Manfredi, Achille Anselmo   +10 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

First proposed panels on acute leukemia for four-color immunophenotyping by flow cytometry from the brazilian group of flow cytometry-gbcflux

, 2016
Multiparameter flow cytometry is a highly sensitive, fast, and specific diagnostic technology with a wide range of applicability in hematology. Although well-established eight-color immunophenotyping panels are already available, most Brazilian clinical ...
Cavalcanti , J.G.B., Costa, E.S., Ikoma, M.R.V., Leandro, T.S., Santos, M.C.S., Metze, I.G.H.L., Yamamoto, M., Pimenta. G., Bacal, N.S., Sandes, A.F., Souto, E.   +10 more
core   +1 more source

Analyzing the involvement of diverse cell death-related genes in diffuse large B-cell lymphoma using bioinformatics techniques

Heliyon
Diffuse large B-cell lymphoma (DLBCL) stands as the most prevalent subtype of non-Hodgkin's lymphoma and exhibits significant heterogeneity. Various forms of programmed cell death (PCD) have been established to have close associations with tumor onset ...
Heyuan Feng, Xiyuan Zhang, Jian Kang
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Bi-lineage acute leukemia; a case with B-lymphoblasts and myeloid blasts [PDF]

Journal of Preventive Epidemiology, 2019
Mixed phenotypic acute leukemia (MPAL) is classified under acute leukemia of ambiguous lineage. Most reported cases of acute ambiguous leukemia belong to bi-phenotypic leukemia. However, bi-lineage leukemia is rare.
Esmaeil Shahabi Satlsar, Farahnaz Ghahremanfard, Anahid Nabavi, Mohammad Moslehabadi Farahani   +3 more
doaj  

Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia

BMC Research Notes, 2018
Objective The objective of this study was to evaluate the cluster of differentiation-38 (CD38) expression in Sudanese patients with chronic lymphocytic leukemia (CLL) and to determine its association with clinical and laboratory characteristics of the ...
Enaam Abdelrhman Abdelgader, Nada Hassan Eltayeb, Tasniem Ahmed Eltahir, Osama Ali Altayeb, Eman Abbass Fadul, Eldirdiri M. Abdel Rahman, Tarig H. Merghani   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source