Results 41 to 50 of about 799,277 (314)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Subcutaneous immunotherapy induces alterations in monocytes and dendritic cells homeostasis in allergic rhinitis patients

Allergy, Asthma & Clinical Immunology, 2018
Background Specific subcutaneous immunotherapy (SCIT) can achieve long-term remission in patients with allergic rhinitis (AR) through complex and still unknown mechanisms.
Letícia Sousa, Carmen Martín-Sierra, Celso Pereira, Graça Loureiro, Beatriz Tavares, Susana Pedreiro, António Martinho, Artur Paiva   +7 more
doaj   +1 more source

Development of a polychromatic flow cytometry panel for the evaluation of HIV-specific T cell responses [PDF]

, 2009
Includes abstract.Includes bibliographical references (leaves 99-115).Investigating T cell responses in HIV infection has revealed several correlates of viral control, but their importance is not fully understood.
Naicker, Prinola
core  

Somatic cell genetics and flow cytometry [PDF]

Human genes coding cell surface molecules can be introduced into mouse host cells using a variety of somatic cell genetic techniques. Because these human gene products can be detected using indirect immunofluorescence on viable cells, the genes ...
Peters, P. G., Kühn, L. C., Shulman, L., Kamarck, M. E., Barbosa, J. A., Ruddle, F. H.   +5 more
core   +1 more source

Outer Limits of Flow Cytometry to Quantify Viruses in Water [PDF]

, 2021
The use of flow cytometry (FCM) with environmental or clinical samples to enumerate viruses (flow virometry) has become popular with the development of sensitive fluorescent dyes that bind to nucleic acids, yet there is no quantitative evidence of the ...
Dey, Rafik, Pollard, Peter C., Dlusskaya, Elena, Ashbolt, Nicholas J, Pollard, Peter C, Ashbolt, Nicholas J.   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Image_5_Performance of spectral flow cytometry and mass cytometry for the study of innate myeloid cell populations.tif [PDF]

, 2023
IntroductionMonitoring of innate myeloid cells (IMC) is broadly applied in basic and translational research, as well as in diagnostic patient care.
Kassem, Sara, Kyra van der Pan (13796077), Khatri, Indu, Brigitta A.E. Naber (15649463), Paula Díez (10052081), Indu Khatri (511338), Jager, Anniek L. de, Suzanne E.T. Comans (15649466), Louis, Alesha, Orfao, Alberto, Dongen, J. J. M. van, Jacques J.M. van Dongen (10153076), Alesha Louis (13796104), Inge F. de Laat (13796089), Alberto Orfao (108164), Hameetman, Marjolijn, Díez, Paula, Cristina Teodosio (143750), Sara Kassem (13796098), Comans, Suzanne, Laat, Inge F. de, Anniek L. de Jager (13796101), Pan, Kyra van der, Naber, Brigitta A. E., Marjolijn Hameetman (6177341), Teodosio, Cristina   +25 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Image_4_Performance of spectral flow cytometry and mass cytometry for the study of innate myeloid cell populations.tif [PDF]

, 2023
IntroductionMonitoring of innate myeloid cells (IMC) is broadly applied in basic and translational research, as well as in diagnostic patient care.
Kassem, Sara, Kyra van der Pan (13796077), Khatri, Indu, Brigitta A.E. Naber (15649463), Paula Díez (10052081), Indu Khatri (511338), Jager, Anniek L. de, Suzanne E.T. Comans (15649466), Louis, Alesha, Orfao, Alberto, Dongen, J. J. M. van, Jacques J.M. van Dongen (10153076), Alesha Louis (13796104), Inge F. de Laat (13796089), Alberto Orfao (108164), Hameetman, Marjolijn, Díez, Paula, Cristina Teodosio (143750), Sara Kassem (13796098), Comans, Suzanne, Laat, Inge F. de, Anniek L. de Jager (13796101), Pan, Kyra van der, Naber, Brigitta A. E., Marjolijn Hameetman (6177341), Teodosio, Cristina   +25 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source