Results 81 to 90 of about 1,011,693 (349)
Flow Cytometry as the Tool to Define Peripheral Blood Leukocyte Signatures in Acute EBV Infection
CellsPrimary Epstein–Barr virus (EBV) infection which can manifest as infectious mononucleosis (IM) is commonly acquired during childhood. EBV primarily invades B cells leading to a lytic reaction; the control of the infection is handled by natural killer and
Pragya Singh +4 more
doaj +1 more source
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. [PDF]
, 2019 Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-
Barkal, Amira A +10 more
core
Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data [PDF]
, 2013 In systems biomedicine, an experimenter encounters different potential sources of variation in data such as individual samples, multiple experimental conditions, and multi-variable network-level responses.
Duong, Tarn +12 more
core +4 more sources
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Leukemia stem cells in acute myeloid leukemia-mimicking “space and time continuum”?
HaematologicaNot available.
Adriana Plesa, Christophe Roumier
doaj +1 more source
Flow Cytometry: An Overview [PDF]
Current Protocols in Immunology, 2018 AbstractFlow cytometry is a technology that provides rapid multi‐parametric analysis of single cells in solution. Flow cytometers utilize lasers as light sources to produce both scattered and fluorescent light signals that are read by detectors such as photodiodes or photomultiplier tubes.
openaire +3 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome
Frontiers in Immunology, 2019 Sepsis remains a major challenge in translational research given its heterogeneous pathophysiology and the lack of specific therapeutics. The use of humanized mouse chimeras with transplanted human hematopoietic cells may improve the clinical relevance ...
Tomasz Skirecki +7 more
doaj +1 more source