Results 81 to 90 of about 5,462,613 (380)

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation [PDF]

, 2014
NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A ...
A Dolan, A Rolle, AJ Bradley, AJ Davison, AK Marsh, AM Arvin, Andrew J. Davison, B Park, BP McSharry, BP McSharry, Brian P. McSharry, C Grahame-Clarke, C Griffin, C Gubser, CA Biron, CC Leong, Ceri A. Fielding, CL Sutherland, D Cosman, D Gatherer, DA Abate, DA Mitchell, Daniel Sugrue, Dawn Roberts, DH Raulet, DM Miller, E Vivier, EC Wang, Eddie C. Y. Wang, EJ Wiertz, EP Browne, Fabien P. Blanchet, FE McCann, Gavin W. G. Wilkinson, GH Lee, GM Venkataraman, I Gabaev, J Wu, James Davies, JC Towler, JD Oram, K Ahn, K Ahn, K Hellstrand, K Weston, M Kubin, M Lesniewski, M Pierer, M Stern, ME Penfold, MH Furman, Michael P. Weekes, MR Wills, MS Chee, N Baryawno, N Henke, N Stern-Ginossar, N Tavalai, NC Elde, NJ Bennett, NJ Chalupny, O Ashiru, P Engel, P Tomasec, P Tomasec, P. Robin Antrobus, Paul J. Lehner, Peter Tomasec, PJ Lehner, R Gazit, RA Eagle, RA Eagle, RA Eagle, Rebecca Aicheler, Richard J. Stanton, RJ Stanton, RJ Stanton, S Das, S Das, S Kim, Sepehr Seirafian, SG Adam, SG Hansen, Simone Cuff, Song Han, T Yamaji, TR Jones, TR Jones, TR Jones, TW Kuijpers, V Prod'homme, V Prod'homme, Virginie Prod'homme, W Dunn, W Smith, William J. Britt, WL Chang, Y Zou, YW Guo   +98 more
core   +5 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells [PDF]

, 2006
Root growth, G2 length, and the frequency of aberrant mitoses and apoptotic nuclei were recorded after a single X-ray irradiation, ranging from 2.5 to 40 Gy, in Allium cepa L. root meristematic cells.
Carballo, Jesús A, de la Torre, Consuelo, Pincheira, Juana   +2 more
core   +4 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Imaging flow cytometry is a powerful tool for analyzing every single cell in a large heterogeneous population but relies on fluorescent labeling, which comes with cytotoxicity, nonspecific binding, and interference with natural cellular ...
Yuta Suzuki, K. Kobayashi, Y. Wakisaka, D. Deng, Shunji Tanaka, Chun-Jung Huang, Cheng Lei, Chia‐Wei Sun, Hanqin Liu, Yasuhiro Fujiwaki, Sangwook Lee, A. Isozaki, Y. Kasai, T. Hayakawa, S. Sakuma, F. Arai, Kenichi Koizumi, H. Tezuka, M. Inaba, K. Hiraki, Takuro Ito, Misa Hase, S. Matsusaka, K. Shiba, Kanako Suga, Masako Nishikawa, M. Jona, Y. Yatomi, Yaxiaer Yalikun, Yo Tanaka, Takeaki Sugimura, Nao Nitta, K. Goda, Y. Ozeki   +33 more
semanticscholar   +1 more source

Hydroxyurea-induced synchronisation of bloodstream stage Trypanosoma brucei [PDF]

, 2009
Synchronisation of the <i>Trypanosoma brucei</i> cell cycle proved elusive for many years. A recent report demonstrated that synchronisation of procyclic form cells was possible following treatment with hydroxyurea.
Forsythe, Glynn R., Hammarton, Tansy C., McCulloch, Richard   +2 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

UVB radiation induced effects on cells studied by FTIR spectroscopy

, 2010
We have made a preliminary analysis of the results about the eVects on tumoral cell line (lymphoid T cell line Jurkat) induced by UVB radiation (dose of 310 mJ/cm^2) with and without a vegetable mixture. In the present study, we have used two techniques:
A. Congiu Castellano, B Fadeel, C Di Pietro, D Pozzi, D. Pozzi, H Tuschl, I. Silvestri, JL Ravant, Lucia Di Giambattista, M Engeland Van, M Hagenhofer, M-E Legaz, M. Grandi, N Gault, N Jamin, P. Grimaldi, PG Andrus, S Gaudenzi, S. Gaudenzi, S. Morrone, SY Chor, Z Novak   +21 more
core   +1 more source

Randomized lasso links microbial taxa with aquatic functional groups inferred from flow cytometry [PDF]

, 2019
High-nucleic-acid (HNA) and low-nucleic-acid (LNA) bacteria are two operational groups identified by flow cytometry (FCM) in aquatic systems. A number of reports have shown that HNA cell density correlates strongly with heterotrophic production, while ...
Biddanda, Bopaiah A, Boon, Nico, Denef, Vincent J, Props, Ruben, Rubbens, Peter, Schmidt, Marian L, Waegeman, Willem   +6 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source