Results 81 to 90 of about 1,073,278 (354)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Impact of high-sensitivity flow cytometry on peri-transplant minimal residual disease kinetics in acute leukemia

Scientific Reports
Minimal residual disease (MRD) detected before hematopoietic cell transplantation (HCT) is associated with adverse outcomes in patients with high-risk acute leukemia.
Ana Paula de Azambuja, Miriam Perlingeiro Beltrame, Mariester Malvezzi, Yara Carolina Schluga, Julie Lillian Pimentel Justus, Alberto Cardoso Martins Lima, Vaneuza Araujo Moreira Funke, Carmem Bonfim, Ricardo Pasquini   +8 more
doaj   +1 more source

A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes

Cells, 2014
Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate.
Miles C. Smith, Andrew C. Box, Jeffrey S. Haug, William S. Lane, David J. Davido   +4 more
doaj   +1 more source

Corrected score methods for estimating Bayesian networks with error-prone nodes [PDF]

arXiv, 2020
Motivated by inferring cellular signaling networks using noisy flow cytometry data, we develop procedures to draw inference for Bayesian networks based on error-prone data. Two methods for inferring causal relationships between nodes in a network are proposed based on penalized estimation methods that account for measurement error and encourage ...
arxiv  

Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog. [PDF]

, 2019
BackgroundEvolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma.
Bienzle, Dorothee, Darzentas, Nikos, Deravi, Nariman, Hwang, Mei-Hua, Keller, Stefan M, Matsuyama, Arata, Richardson, Danielle   +6 more
core   +1 more source

UVB radiation induced effects on cells studied by FTIR spectroscopy

, 2010
We have made a preliminary analysis of the results about the eVects on tumoral cell line (lymphoid T cell line Jurkat) induced by UVB radiation (dose of 310 mJ/cm^2) with and without a vegetable mixture. In the present study, we have used two techniques:
A. Congiu Castellano, B Fadeel, C Di Pietro, D Pozzi, D. Pozzi, H Tuschl, I. Silvestri, JL Ravant, Lucia Di Giambattista, M Engeland Van, M Hagenhofer, M-E Legaz, M. Grandi, N Gault, N Jamin, P. Grimaldi, PG Andrus, S Gaudenzi, S. Gaudenzi, S. Morrone, SY Chor, Z Novak   +21 more
core   +1 more source

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation [PDF]

, 2014
NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A ...
A Dolan, A Rolle, AJ Bradley, AJ Davison, AK Marsh, AM Arvin, Andrew J. Davison, B Park, BP McSharry, BP McSharry, Brian P. McSharry, C Grahame-Clarke, C Griffin, C Gubser, CA Biron, CC Leong, Ceri A. Fielding, CL Sutherland, D Cosman, D Gatherer, DA Abate, DA Mitchell, Daniel Sugrue, Dawn Roberts, DH Raulet, DM Miller, E Vivier, EC Wang, Eddie C. Y. Wang, EJ Wiertz, EP Browne, Fabien P. Blanchet, FE McCann, Gavin W. G. Wilkinson, GH Lee, GM Venkataraman, I Gabaev, J Wu, James Davies, JC Towler, JD Oram, K Ahn, K Ahn, K Hellstrand, K Weston, M Kubin, M Lesniewski, M Pierer, M Stern, ME Penfold, MH Furman, Michael P. Weekes, MR Wills, MS Chee, N Baryawno, N Henke, N Stern-Ginossar, N Tavalai, NC Elde, NJ Bennett, NJ Chalupny, O Ashiru, P Engel, P Tomasec, P Tomasec, P. Robin Antrobus, Paul J. Lehner, Peter Tomasec, PJ Lehner, R Gazit, RA Eagle, RA Eagle, RA Eagle, Rebecca Aicheler, Richard J. Stanton, RJ Stanton, RJ Stanton, S Das, S Das, S Kim, Sepehr Seirafian, SG Adam, SG Hansen, Simone Cuff, Song Han, T Yamaji, TR Jones, TR Jones, TR Jones, TW Kuijpers, V Prod'homme, V Prod'homme, Virginie Prod'homme, W Dunn, W Smith, William J. Britt, WL Chang, Y Zou, YW Guo   +98 more
core   +5 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Flow Cytometry as the Tool to Define Peripheral Blood Leukocyte Signatures in Acute EBV Infection

Cells
Primary Epstein–Barr virus (EBV) infection which can manifest as infectious mononucleosis (IM) is commonly acquired during childhood. EBV primarily invades B cells leading to a lytic reaction; the control of the infection is handled by natural killer and
Pragya Singh, Manisha Gadgeel, Batool AlQanber, Ahmad Farooqi, Süreyya Savaşan   +4 more
doaj   +1 more source

The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome

Frontiers in Immunology, 2019
Sepsis remains a major challenge in translational research given its heterogeneous pathophysiology and the lack of specific therapeutics. The use of humanized mouse chimeras with transplanted human hematopoietic cells may improve the clinical relevance ...
Tomasz Skirecki, Susanne Drechsler, Grazyna Hoser, Mohammad Jafarmadar, Katarzyna Siennicka, Zygmunt Pojda, Jerzy Kawiak, Marcin F. Osuchowski   +7 more
doaj   +1 more source