Results 41 to 50 of about 123,855 (295)

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids

STAR Protocols, 2021
Summary: We developed a modified protocol, based on differential ultracentrifugation (dUC), to isolate extracellular vesicles and particles (specifically exomeres) (EVPs) from various human and murine sources, including cell lines, surgically resected ...
Linda Bojmar, Han Sang Kim, Gabriel C. Tobias, Fanny A. Pelissier Vatter, Serena Lucotti, Kofi Ennu Gyan, Candia M. Kenific, Zurong Wan, Kyung-A Kim, DooA Kim, Jonathan Hernandez, Virginia Pascual, Todd E. Heaton, Michael P. La Quaglia, David Kelsen, Tanya M. Trippett, David R. Jones, William R. Jarnagin, Irina R. Matei, Haiying Zhang, Ayuko Hoshino, David Lyden   +21 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Preparation of tailor-made supported catalysts using asymmetric flow field flow fractionation and their application in hydrogenation

Nanotechnology Reviews, 2014
The optical, chemical, and catalytic properties of metallic nanoparticles (NPs) depend strongly on their particle size and shape. Therefore, the preparation of monodisperse metallic NPs is very important for fundamental studies and practical applications.
Baumgard Jens, Pohl Marga-Martina, Kragl Udo, Steinfeldt Norbert   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Comment on "Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel"

, 2007
[First paragraph] In a recent paper Yamada et al. propose the novel concept of "pinched flow fractionation" (PFF) for the continuous size separation and analysis of particles in microfabricated lab-on-a-chip devices.
Mortensen, Niels Asger
core   +2 more sources

Development of an advanced on-line position-specific stable carbon isotope system and application to methyl tert-butyl ether [PDF]

, 2009
We present an advanced system for on-line position-specific carbon isotope analysis. The main limitation of on-line intramolecular isotope ratio measurements has been that optimal pyrolytic fragments are obtained mostly at temperatures where the analyte ...
Abelson, Barrie, Barth, Benson, Coplen, Corso, Corso, Corso, Daly, Dempster, Dias, Elsner, Elsner, Fischer, Gray, Hall, Hall, Harrington, Hayes, Hirschorn, Huang, Hunkeler, Jasper, Jeffrey, Kolhatkar, Kuder, Mancini, Mariotti, Matthews, Meckenstock, Meier-Augenstein, Meier-Augenstein, Merritt, Miller, Monson, Morrison, O'Sullivan, Poulson, Richnow, Rosell, Sacks, Sano, Schmidt, Schmidt, Schüth, Slater, Slater, Slater, Smallwood, Somsamak, Somsamak, Vogler, Wang, Wolyniak, Wolyniak, Yamada, Zwank   +56 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Partition-Induced Vector Chromatography in Microfluidic Devices

, 2010
The transport of Brownian particles in a slit geometry in the presence of an arbitrary two-dimensional periodic energy landscape and driven by an external force or convected by a flow field is investigated by means of macrotransport theory.
Bahukudumbi, Balvin, Bhagat, Brenner, Brenner, Burada, Carlo, Choi, Choi, Choi, Davis, Dorfman, Dorfman, Eijkel, Ermak, Evander, Frechette, Gascoyne, German Drazer, Giddings, Giddings, Giddings, Giddings, Han, Han, Happel, Herrmann, Huang, Hughes, Jacobs, Jonáš, Jorge A. Bernate, Kovarik, Kowalkowski, Kralj, Kulrattanarak, Laachi, Li, Mao, Morton, Morton, Pamme, Pamme, Park, Pawar, Risken, Sai, Staben, Takagi, Vastamäki, Wang, Wu, Yamada, Yamada, Zwanzig   +54 more
core   +1 more source