Results 51 to 60 of about 6,794,876 (284)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Research on influencing factors and application of phosphorus recovery by induced crystallization method

Gongye shui chuli
With the development of economy and frequent industrial activities by humans, phosphorus is gradually transformed from phosphate ore to phosphate and into water bodies.
QI Zhen, LIU Rupeng, XU Linxu, FANG Jinfeng, ZHU Weichen, FAN Haoyu, QIAO Yimu   +6 more
doaj   +1 more source

Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activityResearch in context

EBioMedicine, 2023
Summary: Background: HexaBody®-CD38 (GEN3014) is a hexamerization-enhanced human IgG1 that binds CD38 with high affinity. The E430G mutation in its Fc domain facilitates the natural process of antibody hexamer formation upon binding to the cell surface,
Ida H. Hiemstra, Kim C.M. Santegoets, Maarten L. Janmaat, Bart E.C.G. De Goeij, Wessel Ten Hagen, Sanne van Dooremalen, Peter Boross, Jeroen van den Brakel, Sieto Bosgra, Grietje Andringa, Berris van Kessel-Welmers, Dennis Verzijl, Richard G. Hibbert, Kristine A. Frerichs, Tuna Mutis, Niels W.C.J. van de Donk, Tahamtan Ahmadi, David Satijn, A. Kate Sasser, Esther C.W. Breij   +19 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

A novel PLA/P(3HB-co-4HB)/MWCNT composite featuring enhanced mechanical properties and excellent thermal stability based on elongational rheology

Polymer Testing, 2022
Simple melt blending is the most frequently-used strategy to obtain high-performance PLA composites. However, the thermosensitive PLA displays the defects of poor thermostability, high brittleness and low heat deformation temperature (HDT) in traditional
Xiaolong Li, Chuanbiao Zhu, Hu Wang, Yang Xiao, Xiang Lu, Yi Li, Zhigang Liu, Yi Tong, Jinping Qu   +8 more
doaj   +1 more source

Modeling of Flow-Induced Crystallization of Particle-Filled Polymers [PDF]

, 2006
We present a study on flow-induced crystallization of polymers filled with rigid particles. The numerical simulations reveal the interplay between filler particles, the polymer melt, flow and flow-induced crystallization.
Hwang, W.R., Peters, G.W.M., Han E. H. Meijer, Meijer, H.E.H., Wook Ryol Hwang, Hulsen, M.A., Martien A. Hulsen, Gerrit W. M. Peters   +7 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Development of Fibrillar Morphology in a Polypropylene Under Time‐Dependent Shear Flow

Macromolecular Materials and Engineering
Polyolefins are among the most widely used polymers due to their versatile applications. The physical properties of these semicrystalline materials, such as crystallinity and crystal orientation, are significantly influenced by processing conditions ...
Vito Speranza, Sara Liparoti, Valentina Volpe, Roberto Pantani   +3 more
doaj   +1 more source

Characterizing the Solvent‐Induced Inversion of Colloidal Aggregation During Electrophoretic Deposition

Advanced Materials Interfaces, 2023
Electrophoretic deposition (EPD) of colloidal particles is a practical system for the study of crystallization and related physical phenomena. The aggregation is driven by the electroosmotic flow fields and induced dipole moments generated by the ...
Justin R. DeMoulpied, Jessica A. Killenbeck, Zebulon G. Schichtl, Babloo Sharma, Susanne Striegler, Robert H. Coridan   +5 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source