Results 131 to 140 of about 2,192,114 (314)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Kidney Research and Clinical Practice, 2013 Background: Prospective access flow measurement is the preferred method for vascular access surveillance in hemodialysis (HD) patients. We studied the effect of intradialytic change in blood pressure and ultrafiltration volume on the variation in access ...
Hoon Suk Park +6 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2012 In refrigeration compressors, the suction and discharge valves are responsible for the retention of the refrigerant from the suction chamber to the cylinder and passage from the cylinder to the discharge chamber.
Barbi, Franco +2 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Scale-up of oscillatory flow mixing
, 2011 Oscillatory Flow Mixing is a recent development in mixing technology which has evolved over the past decade. It has a number of similarities to other mixing technologies, particularly pulsed and reciprocating plate columns, but at the laboratory scale ...
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Flow Mosaicking: Real-time Pedestrian Counting without Scene-specific Learning
, 2009 In this paper, we present a novel algorithm based on flow velocity field estimation to count the number of pedestrians across a detection line or inside a specified region.
Zhu SC(朱松纯) +3 more
core
Large-eddy simulation for flow and dispersion in urban streets
, 2009 Large-eddy simulations (LES) with our recently developed inflow approach (Xie &Castro, 2008a) have been used for flow and dispersion within a genuine city area -the DAPPLE site, located at the intersection of Marylebone Rd and Gloucester Plin Central
Xie, Zheng-Tong +3 more
core +1 more source