Results 91 to 100 of about 108,498 (265)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Influence of flow regime on the decomposition of diluted methane in a nitrogen rotating gliding arc. [PDF]
Sci Rep, 2022 J A, Rao L.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Study on Feasibility of the Vortex Tool for Gas Well Fluid Drainage in Different Flow Regimes
Shiyou jixie, 2018 At present, the mechanism research of vortex tools in China mainly uses Fluent software to simulate the flow field, which ignores the actual flow regime distribution in the wellbore and the applicability of the vortex tool in each flow regime, leading to
Shi Yifan, Yan Tingjun, Zhao Xuhe
doaj
Science and Technology of Nuclear Installations, 2015 In earlier study we have demonstrated that RELAP5 can predict flow instability parameters (flow rate, oscillation period, temperature, and pressure) in single channel tests in CIRCUS-IV facility. The main goals of this work are to (i) validate RELAP5 and
Viet-Anh Phung, Pavel Kudinov
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Gas Damping in Capacitive MEMS Transducers in the Free Molecular Flow Regime. [PDF]
Sensors (Basel), 2021 Boom BA +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Hydrologic variation influences stream fish assemblage dynamics through flow regime and drought. [PDF]
Sci Rep, 2021 Magoulick DD +5 more
europepmc +1 more source