Results 81 to 90 of about 4,208,553 (288)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Frontiers in Ecology and EvolutionClimate-driven shifts in the natural flow regime can threaten species persistence in stream systems, and anticipating such shifts before they occur is critical for conservation.
Ralph W. Tingley +5 more
doaj +1 more source
Rheological behavior of granular materials under different relative densities [PDF]
E3S Web of ConferencesGranular materials typically exhibit complex behaviour especially during shearing under different states. The material behaviour transitions from fluid-like to unfluid-like primarily due to various fundamental mechanisms involved during the shearing ...
Kumar Jithin S., Kandasami Ramesh Kannan
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Fixed versus Flexible: Lessons from EMS Order Flow [PDF]
This paper addresses the puzzle of regime-dependent volatility in foreign exchange. We extend the literature in two ways. First, our microstructural model provides a qualitatively new explanation for the puzzle.
William P. Killeen +2 more
core
, 2010 This work presents a new methodology for flow regimes identification and volume fraction predictions in wateregaseoil multiphase systems. The approach is based on gamma-ray pulse height distributions (PHDs) pattern recognition by means the artificial ...
SALGADO, César Marques +7 more
core +1 more source
MULTIPHASE DRILLING KICK ANNULAR FLOW BEHAVIOUR IN VERTICAL AND INCLINED WELL PROFILES
Platform, a Journal of Engineering, 2021 One of the exponentially important drilling parameter has many misconceptions, and prompt confusion is the drilling kick. The current conventional approach assume a single-phase bubble model and neglect the multiphase flow in the drilling kick ...
Muhammad Fadrul Jamaludeen +1 more
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source