Results 71 to 80 of about 108,291 (265)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Linking Flow Regime and Water Quality in Rivers: a Challenge to Adaptive Catchment Management

open access: yesEcology and Society, 2008
Water quality describes the physicochemical characteristics of the water body. These vary naturally with the weather and with the spatiotemporal variation of the water flow, i.e., the flow regime.
Christer Nilsson   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Effects of irrigation dams on riverine biota in mountain streams

open access: yesFrontiers in Environmental Science
Mountain streams harbor unique biodiversity and provide essential ecosystem services to human societies. Yet, these ecosystems face numerous threats, such as the construction of dams and land use changes, leading to rapid habitat degradation, water ...
Cássia Rocha Pompeu   +2 more
doaj   +1 more source

Hydraulic requirements of freshwater mussels (Unionidae) and a conceptual framework for how they respond to high flows

open access: yesEcosphere, 2019
Spatiotemporal variability in flow determines the physical structures of habitat. During low flows, aquatic organisms can be exposed to reduced dissolved oxygen concentrations, increased water temperature, and desiccation, whereas at high flows ...
Charles R. Randklev   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Classification of the flow regimes in the flow-through cell

open access: yesEuropean Journal of Pharmaceutical Sciences, 2009
This paper examines the dissolution apparatus referred to as the flow-through cell from an engineering fluid mechanics viewpoint. The analysis demonstrates that laminar flow predominantly occurs in the standard operation of this apparatus. It is argued that fully turbulent conditions are unlikely.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Effects of Flow Regimes on Maximum Pressure in Offshore Pipelines [PDF]

open access: yesمهندسی منابع آب, 2019
One of the most important factors in pipeline hydraulics and its protection against probable damages is keeping the pressure in a specific limit and also knowing how the pressure functions in the pipe through the pipeline route.
Zahra Ghadampour, Mohammad sadegh Narges
doaj  

A Three-Regime Theorem for Flow-Firing

open access: yesThe Electronic Journal of Combinatorics
Graphical chip-firing is a discrete dynamical system where chips are placed on the vertices of a graph and exchanged via simple firing moves. Recent work has sought to generalize chip-firing on graphs to higher dimensions, wherein graphs are replaced by cellular complexes and chip firing becomes flow-rerouting along the faces of the complex. Given such
Sarah Brauner   +4 more
openaire   +3 more sources

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