An analysis method for multi-component airfoils in separated flow [PDF]
The multi-component airfoil program (Langley-MCARF) for attached flow is modified to accept the free vortex sheet separation-flow model program (Analytical Methods, Inc.-CLMAX).
Duorak, F. A., Maskew, B., Rao, B. M.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Quantification of the Intraglottal Pressure Induced by Flow Separation Vortices Using Large Eddy Simulation. [PDF]
J Voice, 2021 Farbos de Luzan C +3 more
europepmc +1 more source
Simulation of turbulent transonic separated flow over an airfoil [PDF]
A code developed for simulating high Reynolds number transonic flow fields of arbitrary configuration is described. This code, in conjunction with laboratory experiments, is used to devise and test turbulence transport models which may be suitable in the
Deiwert, G. S. +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Calculation of symmetric and asymmetric vortex seperation on cones and tangent ogives based on discrete vortex models [PDF]
An inviscid discrete vortex model, with newly derived expressions for the tangential velocity imposed at the separation points, is used to investigate the symmetric and asymmetric vortex separation on cones and tangent ogives.
Chin, S., Lan, C. Edward
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Airfoil shape for flight at subsonic speeds [PDF]
, 1976 An airfoil is examined that has an upper surface shaped to control flow accelerations and pressure distribution over the upper surface and to prevent separation of the boundary layer due to shock wave formulation at high subsonic speeds well above the ...
Whitcomb, R. T.
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Hydraulic studies of the irrigation module of combined irrigation systems
Мелиорация и гидротехникаPurpose: to state hydraulic characteristics and determine priority directions for improving the irrigation module design for combined drip and micro-sprinkler irrigation. Materials and methods. The study is based on the joint use of theoretical methods
Mikhail N. Lytov
doaj +1 more source