Results 101 to 110 of about 536,389 (267)

The Holistic Coronary Physiology Display: Calculation of the Flow Separation Index in Vessel-Specific Individual Flow Range during Fractional Flow Reserve Measurement Using 3D Coronary Reconstruction. [PDF]

J Clin Med, 2021
Szabó GT, Üveges Á, Tar B, Ágoston A, Dorj A, Jenei C, Kolozsvári R, Csippa B, Czuriga D, Kőszegi Z.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Performance of various SST models in predicting typical separated flows

Kongqi donglixue xuebao
The phenomenon of flow separation critically influences the flow field structure near aircraft surfaces and their overall performance. This study evaluated the predictive performance of the widely used shear-stress transport (SST) turbulence model and ...
Wenhao Li, Caiyan Rao, Yi Duan, Ding Wang, Yuan Gao, Jian Zhang   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Design of High-Efficiency Jet Lift Enhancement for Flaps Under Propeller Slipstream Influence

Aerospace
Both propeller slipstream and flap jet flow can significantly increase the aircraft lift coefficient. To establish design principles for efficient lift enhancement via jet flow under the influence of slipstream, wind tunnel experiments are conducted on a
Yan Shao, Wanbo Wang, Jiao Sun, Wenyi Chen, Xinhai Zhao, Jiaxin Pan   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Numerical Analysis of Ejector Flow Performance for High-Altitude Simulation

Aerospace
In this study we perform a computational numerical analysis to examine the flow characteristics of a system composed of a rocket engine, supersonic diffuser, and ejector system.
Chae-Hyoung Kim, Chang-Su Park
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Control on Flow Separation over a Cylinder by a Ferrofluid Film Adsorbed by a Magnet

Inventions
Flow separation can lead to increased resistance and vibration generation, which is a difficult problem that cannot be ignored in engineering. In this paper, we propose a method of controlling flow separation by adsorbing ferrofluid onto the surface of a
Chunyun Wei, Hongjia Xie, Zixuan Liu, Xinfeng Zhai, Hongna Zhang, Xiaobin Li   +5 more
doaj   +1 more source