Results 81 to 90 of about 536,389 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Hydrophilic reentrant SLIPS enabled flow separation for rapid water harvesting. [PDF]

Proc Natl Acad Sci U S A, 2022
Guo Z, Boylan D, Shan L, Dai X.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effects of Inflow Deflection Angle on the Stall Formation Mechanism and Flow Field Structure in a Vertical Axial-Flow Pump

Machines
The influence of inflow angle on the stall characteristics of a vertical axial flow pump is investigated numerically by solving the unsteady Reynolds-averaged Navier–Stokes equations.
Fan Meng, Qixiang Hu, Jinhe Liu, Yanjun Li, Guangjian Zhang, Jiaxing Lu   +5 more
doaj   +1 more source

Superamphiphilic Chitosan Cryogels for Continuous Flow Separation of Oil-In-Water Emulsions. [PDF]

ACS Omega, 2022
Gao C, Wang Y, Shi J, Wang Y, Huang X, Chen X, Chen Z, Xie Y, Yang Y.   +8 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Unsteady Flow and Loading Characteristics of Rotating Spheres During Underwater Ejection

Journal of Marine Science and Engineering
This study systematically investigates the evolution of the flow field and cavitation behavior during the underwater launch of a rotating sphere. By comparing surface pressure distribution, cavitation evolution, flow separation locations, and re-entrant ...
Hao Xu, Mingyang Wang, Zhou Zhou, Tiezhi Sun, Guiyong Zhang   +4 more
doaj   +1 more source

Continuous Flow Separation of Red Blood Cells and Platelets in a Y-Microfluidic Channel Device with Saw-Tooth Profile Electrodes via Low Voltage Dielectrophoresis. [PDF]

Curr Issues Mol Biol, 2023
Hewlin RL, Edwards M.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and In vivo assessment of a novel organ perfusion stent for successful flow separation in donation after cardiac death. [PDF]

J Biomater Appl, 2022
Elsisy M, Tillman B, Chau L, Go C, Cho SK, Chun Y.   +5 more
europepmc   +1 more source