Results 61 to 70 of about 536,389 (267)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Numerical Study on the Influence of Inlet Turbulence Intensity on Turbine Cascades

Aerospace
The turbulence intensity of the high-pressure turbine inlet plays an important role in the development of secondary flow and boundary layer evolution in the turbine passage.
Xuan Wu, Yanfeng Zhang, Junqiang Zhu, Xingen Lu   +3 more
doaj   +1 more source

Flow Behavior analysis over the NACA 4412 airfoil at Different angles of attack [PDF]

EPJ Web of Conferences
To design and optimize wings, rotor blades and aircraft, it is essential to have a good understanding of the aerodynamic properties of the wing. The aim of this numerical study is to examine and analyze the aerodynamic characteristics of a NACA4412 ...
El Houjaji Hakim, El Mimouni Ahmed, Mrigua Khalid, Didi Abdessamad, Sadoune Zouhair   +4 more
doaj   +1 more source

Source Separation by Flow Matching

2025 IEEE Workshop on Applications of Signal Processing to Audio and Acoustics (WASPAA)
5 pages, 3 figures, 2 tables, accepted at WASPAA ...
Robin Scheibler, John R. Hershey, Arnaud Doucet, Henry Li   +3 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

EnKF Unsteady Data Assimilation of the Flow Separation Around an Aerofoil

气体物理
To improve the prediction performance of the RANS model for flow separation, the model constants of the SST turbulence model were recalibrated using the unsteady ensemble Kalman filter (EnKF) data assimilation (DA) combined with the particle image ...
Yuyao ZHANG, Chuangxin HE, Yingzheng LIU
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Continuous Flow Separation of Live and Dead Cells Using Gravity Sedimentation. [PDF]

Micromachines (Basel), 2023
Ozcelik A, Gucluer S, Keskin T.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source