Results 61 to 70 of about 570,525 (267)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Source Separation by Flow Matching

2025 IEEE Workshop on Applications of Signal Processing to Audio and Acoustics (WASPAA)
5 pages, 3 figures, 2 tables, accepted at WASPAA ...
Robin Scheibler, John R. Hershey, Arnaud Doucet, Henry Li   +3 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Numerical Study on the Influence of Inlet Turbulence Intensity on Turbine Cascades

Aerospace
The turbulence intensity of the high-pressure turbine inlet plays an important role in the development of secondary flow and boundary layer evolution in the turbine passage.
Xuan Wu, Yanfeng Zhang, Junqiang Zhu, Xingen Lu   +3 more
doaj   +1 more source

Flow Behavior analysis over the NACA 4412 airfoil at Different angles of attack [PDF]

EPJ Web of Conferences
To design and optimize wings, rotor blades and aircraft, it is essential to have a good understanding of the aerodynamic properties of the wing. The aim of this numerical study is to examine and analyze the aerodynamic characteristics of a NACA4412 ...
El Houjaji Hakim, El Mimouni Ahmed, Mrigua Khalid, Didi Abdessamad, Sadoune Zouhair   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

EnKF Unsteady Data Assimilation of the Flow Separation Around an Aerofoil

气体物理
To improve the prediction performance of the RANS model for flow separation, the model constants of the SST turbulence model were recalibrated using the unsteady ensemble Kalman filter (EnKF) data assimilation (DA) combined with the particle image ...
Yuyao ZHANG, Chuangxin HE, Yingzheng LIU
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Continuous Flow Separation of Live and Dead Cells Using Gravity Sedimentation. [PDF]

Micromachines (Basel), 2023
Ozcelik A, Gucluer S, Keskin T.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source