Results 91 to 100 of about 598,432 (318)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Analysis of Non-steady Separated Turbulent Flow in an Asymmetric Plane Diffuser by Direct Numerical Simulations

open access: yesJournal of Fluid Science and Technology, 2010
Direct numerical simulations (DNS) of turbulent flow through an asymmetric plane diffuser, consisting of a flat wall and an inclined wall, were performed using a high-order finite difference method, to reveal the relationship between turbulence and flow ...
Takashi OHTA, Takeo KAJISHIMA
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Control of shock-induced boundary layer separation at supersonic speeds

open access: yes, 2007
PhDThe results of a systematic experimental investigation into the effects that Sub- Boundary Layer Vortex Generators (SBVGs) have on reducing normal shock-induced turbulent boundary layer separation are presented.
Cohen, Giel S, Cohen, Giel S.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Increasing L/D Ratio of Wing by Delaying Flow Separation for Better Aerodynamic Performance [PDF]

open access: yesJournal of Applied Fluid Mechanics
To improve the aerodynamic efficiency of the aircraft, the article focuses on optimizing the L/D ratio through postponement of flow separation. Elevating the L/D ratio leads to diminished drag and delays stall occurrence at high angles of attack (α). The
L. P. Ramesh, V. Mugendiran, G. Sivaraj
doaj   +1 more source

Application of data-driven models to predict the dimensions of flow separation zone. [PDF]

open access: yesEnviron Sci Pollut Res Int, 2023
Gharehbaghi A   +4 more
europepmc   +1 more source

Experimental investigation of the inflection geometry on dual bell nozzle flow behavior

open access: yes, 2011
The altitude adaption of the dual bell nozzle is achieved by the contour inflection, leading to a symmetrical and controlled separation under sea level conditions.
Ralf Stark   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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