Results 91 to 100 of about 536,389 (267)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

High-Throughput Continuous-Flow Separation in a Micro Free-Flow Electrophoresis Glass Chip Based on Laser Microfabrication. [PDF]

Sensors (Basel), 2022
Zhang A, Xu J, Li X, Lin Z, Song Y, Li X, Wang Z, Cheng Y.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Flow Control of a Rim-Driven Propeller Using Vortex Generators for Enhanced Open-Water Performance

Journal of Marine Science and Engineering
Rim-driven propellers (RDPs) have attracted renewed attention as an efficient propulsion concept for integrated electric propulsion systems, yet their structural configuration inherently limits duct geometry modification, and viscous losses associated ...
Ju Seong Bang, Seok Pyo Yoon, Stefano Brizzolara, Spyros A. Kinnas, Hyung Taek Ahn   +4 more
doaj   +1 more source

Quantification of the Intraglottal Pressure Induced by Flow Separation Vortices Using Large Eddy Simulation. [PDF]

J Voice, 2021
Farbos de Luzan C, Oren L, Gutmark E, Khosla SM.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

On the Aerodynamic Characteristics of the Aurel Persu Car

Engineering Proceedings
This study investigates the aerodynamics of Romanian engineer Aurel Persu’s car through wind tunnel experiments involving force measurements, Particle Image Velocimetry (PIV), and CFD simulations.
Adrian Clenci, Amélie Danlos, Ivan Dobrev, Victor Iorga-Simăn   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Oscillation Modes of Transonic Buffet on a Laminar Airfoil

Aerospace
This paper presents an experimental investigation of unsteady phenomena in shock wave/boundary-layer interaction on natural laminar flow airfoils at transonic speeds. Two airfoils of different relative thickness were studied over a Mach number range of M
Pavel Polivanov, Andrey Sidorenko
doaj   +1 more source