Results 51 to 60 of about 6,048,963 (333)

Research on ladle nozzle clogging during continuous casting of non-oriented electrical steel with high silicon [PDF]

open access: yesArchives of Metallurgy and Materials, 2019
To figure out the reason causing ladle nozzle clogging during CC (continuous casting) of a non-oriented electrical steel with high silicon (or HNO for short) and get a method to address it, this paper studied the theoretical calculation of flow rates ...
Wei Kong, Da-Qiang Cang
doaj   +1 more source

Single-cell western blotting. [PDF]

open access: yes, 2014
To measure cell-to-cell variation in protein-mediated functions, we developed an approach to conduct ∼10(3) concurrent single-cell western blots (scWesterns) in ∼4 h.
Herr, Amy E   +5 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Simulation Analysis of Flow Characteristics of Improved Rectangular Throttling Groove Slide Valve Port

open access: yesJournal of Harbin University of Science and Technology
In view of the problem that the static characteristics of the slide valve can affect the performance of the hydraulic servo system,the software simulation method is mainly used to analyze the pressure,flow velocity and flow distribution law of the ...
WU Yueneng   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Evaluation of Flow-Induced Shear in a Porous Microfluidic Slide: CFD Analysis and Experimental Investigation

open access: yesFluids
Microfluidic devices offer well-defined physical environments that are suitable for effective cell seeding and in vitro three-dimensional (3D) cell culture experiments.
Manoela Neves   +5 more
doaj   +1 more source

3D seismic evidence of internal structure within Tampen Slide deposits on the North Sea Fan : are chaotic deposits that chaotic? [PDF]

open access: yes, 2010
The seismic character of slide deposits is typically described as structureless or chaotic. However, 3D seismic data from the northern flank of the North Sea Fan reveal recognizable internal, penetrative structures within the Tampen Slide deposits.
Evans, D.   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Calculation of lubricant flow in the slide bearing of the aviation engine reducer

open access: yesВестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2019
A method has been developed for calculating the pressure distribution in a cylindrical slide bearing. We present the process of designing a heavy-duty slide bearing as a component of the reduction gearbox of a bypass turbojet engine as the object of our ...
M. V. Siluyanova, A. О. Fertikov
doaj   +1 more source

Robust Simulation for Hybrid Systems: Chattering Path Avoidance [PDF]

open access: yes, 2015
The sliding mode approach is recognized as an efficient tool for treating the chattering behavior in hybrid systems. However, the amplitude of chattering, by its nature, is proportional to magnitude of discontinuous control.
Aljarbouh, Ayman, Caillaud, Benoit
core   +5 more sources

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