Results 91 to 100 of about 7,809,143 (340)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Numerical analysis of a penalization method for the three-dimensional motion of a rigid body in an incompressible viscous fluid

, 2009
We present and analyze a penalization method wich extends the the method of [1] to the case of a rigid body moving freely in an incompressible fluid. The fluid-solid system is viewed as a single variable density flow with an interface captured by a level
Bost, Claire, Cottet, Georges-Henri, Maitre, Emmanuel   +2 more
core   +3 more sources

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Investigation of exit-velocity stratification effects on jets in a crossflow (STRJET) [PDF]

, 1974
Program determines flow field about jets with velocity stratification exhausting into crossflow. Jets with three different types of exit-velocity stratification have been considered: (a) jets with relatively high-velocity core, (b) jets with relatively ...
Ziegler, H.
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Aluminium extrusion analysis by the finite volume method [PDF]

, 2013
Present work proposes a novel numerical scheme to calculate stress and velocity fields of metal flow in axisymmetric extrusion process in steady state.
Bressan, Jose D., Button, Sergio T., Martins, Marcelo M.   +2 more
core  

Measurements of the Yield Stress in Frictionless Granular Systems

, 2005
We perform extensive molecular dynamics simulations of 2D frictionless granular materials to determine whether these systems can be characterized by a single static yield shear stress.
Corey S. O’Hern, D. J. Evans, F. Albano, M. P. Allen, Ning Xu, P. A. Cundall, W. H. Press   +6 more
core   +1 more source

Hall and ion slip effects on unsteady MHD free convective rotating flow through a saturated porous medium over an exponential accelerated plate

, 2020
In this paper, we have investigated the Hall and ion slip effects on the unsteady magnetohydrodynamic (MHD) free convective rotating flow over an exponentially accelerated inclined plate entrenched in a saturated porous medium with the effect of angle of
M. Veera Krishna, N. Ameer Ahamad, Ali J. Chamkha   +2 more
semanticscholar   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source