Results 71 to 80 of about 7,809,143 (340)

Rapid granular flows on a rough incline: phase diagram, gas transition, and effects of air drag

open access: yes, 2006
We report experiments on the overall phase diagram of granular flows on an incline with emphasis on high inclination angles where the mean layer velocity approaches the terminal velocity of a single particle free falling in air.
GDR MiDi   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Impulse distributions in dense granular flows: signatures of large-scale spatial structures

open access: yes, 2003
In this paper we report the results of simulations of a 2D gravity driven, dissipative granular flow through a hopper system. Measurements of impulse distributions P(I) on the simulated system show flow-velocity-invariant behavior of the distribution for
A Ferguson   +5 more
core   +1 more source

Statistics of pressure and of pressure-velocity correlations in isotropic turbulence [PDF]

open access: yes, 2000
Some pressure and pressure-velocity correlation in a direct numerical simulations of a three-dimensional turbulent flow at moderate Reynolds numbers have been analyzed.
Arad I.   +13 more
core   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Complex of protection structures on the Shakh River in the Krasnodar Territory

open access: yesМелиорация и гидротехника
Purpose: to substantiate a set of measures to ensure reliable protection of the river bank and structures from the impact of water flow and floating objects. Materials and methods. A set of measures to ensure protection of the river bank and structures
Alexander M. Anokhin   +1 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Method for driving two-phase turbines with enhanced efficiency [PDF]

open access: yes, 1985
A method for driving a two phase turbine characterized by an output shaft having at least one stage including a bladed rotor connected in driving relation with the shaft is described.
Elliott, D. G.
core   +1 more source

Solvable Optimal Velocity Models and Asymptotic Trajectory

open access: yes, 1996
In the Optimal Velocity Model proposed as a new version of Car Following Model, it has been found that a congested flow is generated spontaneously from a homogeneous flow for a certain range of the traffic density.
B. S. Kerner   +18 more
core   +2 more sources

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