Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity [PDF]
eLife, 2023 The Arabidopsis thaliana FLAGELLIN-SENSITIVE2 (FLS2), a typical receptor kinase, recognizes the conserved 22 amino acid sequence in the N-terminal region of flagellin (flg22) to initiate plant defense pathways, which was intensively studied in the past ...
Yaning Cui +9 more
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Mutations in FLS2 Ser-938 dissect signaling activation in FLS2-mediated Arabidopsis immunity. [PDF]
PLoS Pathogens, 2013 Flagellin-sensing 2 (FLS2) is a leucine-rich repeat/transmembrane domain/protein kinase (LRR-RLK) that is the plant receptor for bacterial flagellin or the flagellin-derived flg22 peptide.
Yangrong Cao +6 more
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ESCRT-I mediates FLS2 endosomal sorting and plant immunity. [PDF]
PLoS Genetics, 2013 The plant immune receptor FLAGELLIN SENSING 2 (FLS2) is present at the plasma membrane and is internalized following activation of its ligand flagellin (flg22).
Thomas Spallek +6 more
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FLS2-BAK1 extracellular domain interaction sites required for defense signaling activation. [PDF]
PLoS ONE, 2014 Signaling initiation by receptor-like kinases (RLKs) at the plasma membrane of plant cells often requires regulatory leucine-rich repeat (LRR) RLK proteins such as SERK or BIR proteins.
Teresa Koller, Andrew F Bent
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Flagellin recognition triggers zinc mobilization in Arabidopsis thaliana as a response to Salmonella Typhimurium invasion [PDF]
Scientific ReportsSalmonella enterica serovar Typhimurium can enter and colonize the apoplast of plants, including the edible ones, making them a potential reservoir for the pathogen and a route for human contamination.
Tulasi Abhinya Mandava +6 more
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Peptide signaling at the intersection of growth, nutrient sensing, and stress responses. [PDF]
Plant JSUMMARY Plant endogenous peptides emerge as central regulators of multiple aspects of plant physiology. They are secreted from cells and perceived by plasma membrane localized receptors, which activate downstream signaling pathways to regulate growth and development. In addition, endogenous peptides coordinate physiology with their environment.
Zecua-Ramirez P, Jha V, Stegmann M.
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Phytosulfokine signalling blocks mycotoxin toxicity in Arabidopsis and mediates suppression of cell death activated by bacterial microbe-associated molecular patterns. [PDF]
New PhytolSummary Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide biosynthesis and kills plants. Prior activation with bacterial microbe‐associated molecular patterns (MAMPs), such as components of bacterial flagella, effectively suppresses FB1‐induced cell death.
Alqarni AO +3 more
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Reprogramming of flagellin receptor responses with surrogate ligands [PDF]
Nature CommunicationsReceptor kinase (RK) families process information from small molecules, short peptides, or glycan ligands to regulate core cellular pathways in plants. To date, whether individual plant RKs are capable of processing signals from distinct types of ligands
Du-Hwa Lee +12 more
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A large-scale screening identifies receptor-like kinases with common features in kinase domains that are potentially related to disease resistance in planta [PDF]
Frontiers in Plant ScienceIntroductionThe plant genome encodes a plethora of proteins with structural similarity to animal receptor protein kinases, collectively known as receptor-like protein kinases (RLKs), which predominantly localize to the plasma membrane where they activate
Yan Huang +10 more
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Membranes, 2023 Plant cell signaling often relies on the cellular organization of receptor-like kinases (RLKs) within membrane nanodomains to enhance signaling specificity and efficiency. Thus, nanometer-scale quantitative analysis of spatial organizations of RLKs could
Jeremiah Traeger +4 more
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