Results 91 to 100 of about 87,404 (254)

Paediatric Acute Generalised and Localised Exanthematous Pustulosis: A Systematic Review

JEADV Clinical Practice, EarlyView.
Miranda K. Branyiczky, Megan Lowe, Eric McMullen, Shireen Dumont, Narachai Julanon, Vincent Piguet, Cathryn Sibbald   +6 more
wiley   +1 more source

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, EarlyView.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]

, 2019
Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina, Jamison, Matthew T, Molinski, Tadeusz F, Wang, Xiao   +3 more
core  

Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27‐Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran, Maedbh Rhatigan, Zelia Chiu, Jasmine Lichtenstein, Penelope J. Allen, Rosie C. H. Dawkins   +5 more
wiley   +1 more source

High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

BMC Infectious Diseases, 2018
Background The 2010 Infectious Diseases Society of America (IDSA) guidelines for management of cryptococcal diseases recommend high dose fluconazole (≥ 800 mg/day), either alone or with other antifungal drugs, as alternative anticryptococcal choices. But
Hua-Zhen Zhao, Rui-Ying Wang, Xuan Wang, Ying-Kui Jiang, Ling-Hong Zhou, Jia-Hui Cheng, Li-Ping Huang, Thomas Stephen Harrison, Li-Ping Zhu   +8 more
doaj   +1 more source

Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis [PDF]

, 2013
Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections.
Bocanegra, Rosie, Kirkpatrick, William R., Najvar, Laura K., Patterson, Thomas F., Sorrell, Tania C., Wiederhold, Nathan P.   +5 more
core   +1 more source

Improvements in Real‐World Survival in the Setting of a Recent Paradigm Shift in Acute Myeloid Leukemia Treatment

European Journal of Haematology, EarlyView.
ABSTRACT Therapeutic options for newly diagnosed (ND) acute myeloid leukemia (AML) have increased in recent years, leading to a shift in the treatment paradigm from conventional, intensive chemotherapy toward targeted and less intensive therapy. Since 2017, there has been a surge in FDA approvals for novel therapies, including small molecule inhibitors
Thuy N. Ho, Patrick Willard, Graeme F. Murray, Li Liu, Nolan Wages, Hyun Lee, Keri R. Maher   +6 more
wiley   +1 more source

Comparison of antifungal effects of an experimental fluconazole mouthwash and nystatine mouthwash: An in vitro study

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Treatment of oral candidiasis with mouthwashes has several advantages. The aim of the present study was to evaluate the clinical efficacy of a new fluconazole suspension on the Candida albicans and compare its effects with those of nystatin.
Nader Navabi, Ehsan Momeni, Amin Ayatollahi, Payam Khazaeli, Abbas Pardakhti   +4 more
doaj  

Candida albicans enhances iron uptake to maintain fluconazole resistance

Infection and Immunity
Widespread use of fluconazole has led to the emergence of fluconazole-resistant (FR) Candida spp. causing challenges in clinical treatment. Iron, an essential nutrient, affects the levels of ergosterol (a fluconazole target) in fungal membranes.
Rishabh Sharma, Anubhav Nahar, Sumant Puri   +2 more
doaj   +1 more source

First hospital outbreak of the globally emerging Candida auris in a European hospital [PDF]

, 2016
Background: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016.
Abdolrasouli, A, Armstrong-James, DPH, Chowdhary, A, Fisher, MC, Hagen, F, Hall, A, Meis, JF, Rhodes, JL, Ryan, L, Schelenz, S, Shackleton, J, Trimlett, R   +11 more
core   +2 more sources