Results 41 to 50 of about 82,470 (284)

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights from 13C and 1H Solid‐State NMR

Angewandte Chemie International Edition, Accepted Article.
Cryptococcus species are major fungal pathogens responsible for life‐threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence‐associated layers, melanin and capsule, rendering them ...
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink-Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang   +11 more
wiley   +1 more source

Fluconazole resistance in non-albicans Candida species in the United States, 2012-2021

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Background: Candida spp can cause a variety of infections known as candidiasis, ranging from severe invasive infections to superficial mucosal infections of the mouth and vagina.
Emily Jenkins, Meghan Lyman, Brendan Jackson, Shawn Lockhart, Hannah Wolford, Sujan Reddy, James Baggs   +6 more
doaj   +1 more source

Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. [PDF]

, 2019
Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral ...
Beyene, T, Boulware, DR, Katende, A, Letang, E, Rajasingham, R, Wake, RM   +5 more
core   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata

Frontiers in Cellular and Infection Microbiology
IntroductionWith the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Candida species, particularly C. albicans and non-albicans Candida species such as C.
Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo   +4 more
doaj   +1 more source

Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicans [PDF]

, 2016
Some compounds, characterized by phenylethenyl moiety, such as methyl cinnamate and caffeic acid phenethyl ester, are able to inhibit C. albicans biofilm formation.
Costi, Roberta, D'Auria, Felicia Diodata, DE VITA, Daniela, DI SANTO, Roberto, Pandolfi, Fabiana, Scipione, Luigi, Simonetti, Giovanna   +6 more
core   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from a North India region

Journal of Global Antimicrobial Resistance, 2020
Introduction: Fluconazole resistance in Candida tropicalis health care–associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. Materials and methods: A total
Nidhi Pandey, Muktanand Tripathi, Munesh K. Gupta, Ragini Tilak   +3 more
doaj  

Implications of antimicrobial combinations in complex wound biofilms containing fungi [PDF]

, 2017
Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of ...
Alvarez, Brem, Chellan, Chellan, Craig Williams, Donald Hansom, Dubský, Edmonds, Eleanor M. Townsend, Gordon Ramage, James, John Butcher, Kalan, Kean, Kong, Leighann Sherry, Miles, National Institute for Health and Care Excellence, Neut, Ramage, Ryan Kean, Sanchez, Sanchez, Sherry, Sherry, Smith, Townsend, William G. Mackay   +27 more
core   +3 more sources

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant Staphylococcus aureus by Coordination to Rhenium Carbonyl Complexes

ChemBioChem, Accepted Article.
In this study, a library of rhenium di‐ and tricarbonyl complexes featuring various antimicrobial azoles as monodentate ligands was synthesized and characterized. Their antimicrobial activity was evaluated against both methicillin‐sensitive (MSSA) and methicillin‐resistant (MRSA) Staphylococcus aureus, and selected compounds were also assessed for ...
Kevin Schindler, Gozde Demirci, Bettina Tran, Sara Nasiri Sovari, Youri Cortat, Nicolas F. Rosa De Sousa, Carola Velti, Baptiste Chapuis, Aurélien Crochet, Aleksandar Pavic, Jelena Djuris, Stefan Salentinig, Fabio Zobi   +12 more
wiley   +1 more source