Results 81 to 90 of about 82,470 (284)

A mitochondria‐targeted aggregation‐induced emission photosensitizer for eradication Candida biofilms and treating oral ulcer

Smart Molecules, EarlyView.
A mitochondria‐targeted AIE photosensitizer, LIQ‐TPA‐TZ, was developed to fight against Candida infection. It can efficiently produce reactive oxygen species to kill Candida guilliermondii and eradicate biofilms. It not only disrupted the respiratory chain and affected the metabolism and energy supply but also reduced the fungi adhesion and filament ...
Kun‐Mei Liu, Yun Wang, Feng‐Wei Xia, Shun Feng, Xiao‐Qi Yu, Ming‐Yu Wu   +5 more
wiley   +1 more source

Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections

Brazilian Journal of Infectious Diseases, 2018
Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid.
Letícia Aparecida Schiave, Erika Nascimento, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Cristiane Masetto de Gaitani, Roberto Martinez   +6 more
doaj  

High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

BMC Infectious Diseases, 2018
Background The 2010 Infectious Diseases Society of America (IDSA) guidelines for management of cryptococcal diseases recommend high dose fluconazole (≥ 800 mg/day), either alone or with other antifungal drugs, as alternative anticryptococcal choices. But
Hua-Zhen Zhao, Rui-Ying Wang, Xuan Wang, Ying-Kui Jiang, Ling-Hong Zhou, Jia-Hui Cheng, Li-Ping Huang, Thomas Stephen Harrison, Li-Ping Zhu   +8 more
doaj   +1 more source

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

Brazilian Journal of Infectious Diseases
In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility ...
Liliane Alves Scheid, Débora Alves Nunes Mario, Thaís Felli Kubiça, Janio Morais Santurio, Sydney Hartz Alves   +4 more
doaj   +1 more source

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

Nature Communications, 2020
The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C.
Kali R. Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M. Pimentel-Elardo, Jen L. Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, José F. Muñoz, Sang Hu Kim, John A. Porco, Christina A. Cuomo, Noelle S. Williams, Ashraf S. Ibrahim, John E. Edwards, David R. Andes, Justin R. Nodwell, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen   +21 more
doaj   +1 more source

Cryptococcal meningitis due to Cryptococcus neoformans VNI in a koala (Phascolarctos cinereus) with progressive neurological disease

Australian Veterinary Journal, EarlyView.
Nearly all cases of cryptococcosis in koalas are caused by Cryptococcus gattii species complex. A rare case of meningitis due to Cryptococcus neoformans VNI/AFLP1 (abbreviated VNI) is described in a koala with nasal colonisation by both species complexes.
A Teh, R Crisman, E Dwars, R Malik, LH de Miranda, W Meyer, M Krockenberger   +6 more
wiley   +1 more source

Comparison of antifungal effects of an experimental fluconazole mouthwash and nystatine mouthwash: An in vitro study

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Treatment of oral candidiasis with mouthwashes has several advantages. The aim of the present study was to evaluate the clinical efficacy of a new fluconazole suspension on the Candida albicans and compare its effects with those of nystatin.
Nader Navabi, Ehsan Momeni, Amin Ayatollahi, Payam Khazaeli, Abbas Pardakhti   +4 more
doaj  

Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Therapeutic drug monitoring for astronauts faces limitations in conventional blood sampling and sample management onboard the international space station. Here, we explore the feasibility of dried blood spot (DBS) collection during parabolic flights (PF) to overcome these constraints.
Audrey Derobertmasure, Li Shean Toh, Céline Verstuyft, Srboljub Lukic, Christelle De Sousa Carvalho, Raphaël Couronné, Marie Beauvalet, Stéphanie Chhun, Pierre Boutouyrie   +8 more
wiley   +1 more source

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans

Current Medical Mycology, 2017
Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades.
Fahimeh Alizadeh, Alireza Khodavandi, Sara Zalakian   +2 more
doaj