Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy
Annals of Neurology, Volume 98, Issue 5, Page 991-1003, November 2025.Objective Exenatide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, has neuroprotective effects in preclinical models of multiple system atrophy (MSA). We investigated these effects in a proof‐of‐concept clinical trial. Methods In this single‐center, randomized, open label trial, participants with MSA were randomly assigned (1:1) to receive ...
Nirosen Vijiaratnam +29 more
wiley +1 more source
A simple and robust method for connecting small-molecule drugs using gene-expression signatures [PDF]
, 2008 Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar ...
B Efron +20 more
core +5 more sources
Cardiovascular abnormalities and impaired exercise performance in adolescents with congenital adrenal hyperplasia [PDF]
, 2015 Context: Patients with classic Congenital Adrenal Hyperplasia (CAH) are treated with lifelong glucocorticoids (GCS). Cardiovascular (CV) and metabolic effects of such therapy in adolescents have never been quantified.
Alessio, Maria +10 more
core +1 more source
Exercise induced collapse: neurocardiogenic syncope [PDF]
, 2009 This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of exercise induced collapse caused by neurocardiogenic ...
Chang, Tony
core
Trials, 2011 Background Traumatic brain injury (TBI) is a main cause of severe prolonged disability of young patients. Hospital acquired pneumonia (HAP) add to the morbidity and mortality of traumatic brain-injured patients. In one study, hydrocortisone for treatment
Asehnoune Karim +3 more
doaj +1 more source
The hepatoadrenal syndrome: A common yet unrecognized clinical condition [PDF]
, 2005 Objective: Adrenal failure is common in critically ill patients, particularly those with sepsis. As liver failure and sepsis are both associated with increased circulating levels of endotoxin and proinflammatory mediators and reduced levels of apoprotein-
Acton +51 more
core +1 more source
Primary dysfunction of the afferent limb of the arterial baroreceptor reflex system in a patient with severe supine hypertension and orthostatic hypotension [PDF]
, 1982 A 33 year old man with a history of recurrent episodes of orthostatic dizziness since adolescence was noted to have a supine blood pressure of 200/120 mm Hg and a standing blood pressure of 90/60 mm Hg.
Kochar, Mahendr S. +2 more
core +1 more source
The use of desoxycorticosterone pivalate in dogs with hypoadrenocorticism : a retrospective study of eight cases [PDF]
, 2018 In this article, the use of desoxycorticosterone pivalate is retrospectively reviewed in eight dogs with primary hypoadrenocorticism, presented at the Small Animal Department of Ghent University.
Albers, Maai +3 more
core
What have we learned about primary liver transplantation under tacrolimus immunosuppression? - Long-term follow-up of the first 1000 patients [PDF]
, 1999 Objective: To summarize the long-term efficacy and safety of tacrolimus in orthotopic liver transplant (OLT) recipients, as well as to examine the factors that influence long-term morbidity and mortality rates. Background: Tacrolimus (FK506, Prograf) was
Abu-Elmagd, K +6 more
core +2 more sources