Results 111 to 120 of about 4,388,444 (360)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Injection And Infusion Technology Disruption For Use In MRI

open access: yesMedical Devices: Evidence and Research, 2019
M Kalmar, A Boese, R Landes, M Friebe Intelligente Katheter INKA, Otto-Von-Guericke University Magdeburg, Magdeburg, GermanyCorrespondence: M KalmarIntelligente Katheter INKA, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, Magdeburg 39106,
Kalmar M, Boese A, Landes R, Friebe M
doaj  

Fluid overload

open access: yesIndian Journal of Ophthalmology, 2021
Jyoti Matalia, Ashwini Chandramouli
openaire   +3 more sources

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