Results 41 to 50 of about 286,703 (251)

Association of positive fluid balance and cardiovascular complications after thoracotomy for noncancer lesions

Risk Management and Healthcare Policy, 2014
Tanyong Pipanmekaporn,1,2 Yodying Punjasawadwong,2 Somrat Charuluxananan,3 Worawut Lapisatepun,2 Pavena Bunburaphong,3 Somchareon Saeteng41Clinical Epidemiology Program, 2Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang ...
Pipanmekaporn T, Punjasawadwong Y, Charuluxananan S, Lapisatepun W, Bunburaphong P, Saeteng S   +5 more
doaj  

Beneficial effects of negative fluid balance in preventing global increased permeability syndrome of septic shock patient

Bali Journal of Anesthesiology, 2020
Fluid is considered a successful tool for resuscitation based on the worldwide guideline for sepsis since 2001. However, recent publications have studied of a deleterious effect of overload in fluid resuscitation.
M Azhari Taufik, Vera Irawany, Marilaeta Cindryani   +2 more
doaj   +1 more source

Impact of Time-Varying Intensity of Mechanical Ventilation on 28-Day Mortality Depends on Fluid Balance in Patients With Acute Respiratory Distress Syndrome: A Retrospective Cohort Study

Frontiers in Medicine, 2022
BackgroundRecent studies have mainly focused on the association between baseline intensity of mechanical ventilation (driving pressure or mechanical power) and mortality in acute respiratory distress syndrome (ARDS). It is unclear whether the association
Weiwei Hu, Suming Zhang, Zhengyu He, Yang Zhou, Ziwen Wang, Yang Zhang, Baohe Zang, Wenjing Zhao, Yali Chao   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest

Frontiers in Nutrition, 2017
BackgroundLow levels of caffeine ingestion do not induce dehydration at rest, while it is not clear if larger doses do have an acute diuretic effect. The aim of the present investigation was to examine the acute effect of low and high levels of caffeine,
Adam D. Seal, Costas N. Bardis, Anna Gavrieli, Petros Grigorakis, J. D. Adams, Giannis Arnaoutis, Mary Yannakoulia, Stavros A. Kavouras, Stavros A. Kavouras   +8 more
doaj   +1 more source

The effects of betaine supplementation on fluid balance and heat tolerance during passive heat stress in men

Physiological Reports, 2023
Introduction Consuming intracellular osmolytes, like betaine (BET), may attenuate symptoms of heat stress. The purpose of this study was to examine the effects of BET supplementation on fluid balance and heat tolerance after a 7‐day loading period and ...
Brandon D. Willingham, Liliana I. Rentería, Tristan J. Ragland, Michael J. Ormsbee   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Predictors of bronchopulmonary dysplasia occurrence and severity in extremely preterm infants

Frontiers in Pediatrics
BackgroundBronchopulmonary dysplasia (BPD) is a common complication in extremely preterm infants (EPIs), and there is currently a lack of effective preventive strategies.
Xuejing Liu, Xuejing Liu, Xuejing Liu, Wanxian Zhang, Wanxian Zhang, Wanxian Zhang, Fangrui Ding, Fangrui Ding, Fangrui Ding   +8 more
doaj   +1 more source