Results 61 to 70 of about 234,721 (311)

Prominence of the tropics in the recent rise of global nitrogen pollution

Nature Communications, 2019
Nitrogen pollution is influenced by many stressors, and their combined effects are poorly constrained. Here the authors used a global land biosphere model to analyse the past two and a half centuries of land N pollution budgets and fluxes to the ocean ...
Minjin Lee, Elena Shevliakova, Charles A. Stock, Sergey Malyshev, P. C. D. Milly   +4 more
doaj   +1 more source

Enigma of cerebrospinal fluid dynamics [PDF]

Croatian Medical Journal, 2014
Cerebrospinal fluid (CSF) is a major part of the central nervous system (CNS) extracellular fluid, and fine regulation of its composition is vital to the brain’s health. Despite over a hundred years of CSF dynamics study, many of its aspects are still insufficiently understood.
Klarica, Marijan, Orešković, Darko
openaire   +6 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Photoacclimation and Photoadaptation Sensitivity in a Global Ocean Ecosystem Model

Journal of Advances in Modeling Earth Systems
Chlorophyll underpins ocean productivity yet simulating chlorophyll across biomes, seasons and depths remains challenging for earth system models. Inconsistencies are often attributed to misrepresentation of the myriad nutrient supply, growth and loss ...
Charles A. Stock, John P. Dunne, Jessica Y. Luo, Andrew C. Ross, Nicolas VanOostende, Niki Zadeh, Theresa J. Cordero, Xiao Liu, Yi‐Cheng Teng   +8 more
doaj   +1 more source

The dynamics of quantum fluids

We review experimental and theoretical progress in the physical description of the dynamics of the quantum fluids \he4 and \he3. Historically, the elementary excitations in these systems have been identified as phonons and rotons and, in \he3, collective zero sound and spin-fluctuations.
Godfrin, Henri, Krotscheck, Eckhard
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Exploring multiyear-to-decadal North Atlantic sea level predictability and prediction using machine learning

npj Climate and Atmospheric Science
Coastal communities face substantial risks from long-term sea level rise and decadal sea level variations, with the North Atlantic and U.S. East Coast being particularly vulnerable under changing climates. Employing a self-organizing map-based framework,
Qinxue Gu, Liping Zhang, Liwei Jia, Thomas L. Delworth, Xiaosong Yang, Fanrong Zeng, William F. Cooke, Shouwei Li   +7 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Characterization of dynamic stall of a wind turbine airfoil with a high Reynolds number [PDF]

Wind Energy Science
This study shows an extensive analysis of dynamic stall on wind turbine airfoils, preparing for the development of a reduced-order model applicable to thick airfoils (t/c>0.21) in the future.
H. R. Kim, J. A. Printezis, J. D. Ahrens, J. R. Seume, L. Wein   +4 more
doaj   +2 more sources