Results 81 to 90 of about 6,080,447 (331)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Large eddy simulations of methane oxidation at ultra-wet conditions in a model gas turbine combustor applying detailed chemistry

Journal of Fluid Science and Technology, 2014
The addition of steam to the combustion process is a promising avenue, in order to reduce harmful emissions and simultaneously increase the efficiency. In contrast to traditional flames where the heat release exhibits a thin flame front, operating under ...
Oliver KRÜGER, Christophe DUWIG, Steffen TERHAAR, Christian Oliver PASCHEREIT   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

On the Flight Control of Flapping Wing Micro Air Vehicles with Model-Based Reinforcement Learning

Proceedings
Hummingbirds and insects can hover in disturbed conditions, escape from predators with a very fast response, fly for miles without landing, etc [...]
Romain Poletti, Lilla Koloszar, Miguel Alfonso Mendez   +2 more
doaj   +1 more source

Prominence of the tropics in the recent rise of global nitrogen pollution

Nature Communications, 2019
Nitrogen pollution is influenced by many stressors, and their combined effects are poorly constrained. Here the authors used a global land biosphere model to analyse the past two and a half centuries of land N pollution budgets and fluxes to the ocean ...
Minjin Lee, Elena Shevliakova, Charles A. Stock, Sergey Malyshev, P. C. D. Milly   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Photoacclimation and Photoadaptation Sensitivity in a Global Ocean Ecosystem Model

Journal of Advances in Modeling Earth Systems
Chlorophyll underpins ocean productivity yet simulating chlorophyll across biomes, seasons and depths remains challenging for earth system models. Inconsistencies are often attributed to misrepresentation of the myriad nutrient supply, growth and loss ...
Charles A. Stock, John P. Dunne, Jessica Y. Luo, Andrew C. Ross, Nicolas VanOostende, Niki Zadeh, Theresa J. Cordero, Xiao Liu, Yi‐Cheng Teng   +8 more
doaj   +1 more source

Geophysical Fluid Dynamics Laboratory [PDF]

Located in Princeton, New Jersey, GFDL conducts research where the goal is to expand the scientific understanding of the physical processes that govern the behavior of the atmosphere and the oceans as complex fluid systems.

core   +2 more sources

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

Fluids and Barriers of the CNS, 2019
The fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted.
S. Bothwell, D. Janigro, A. Patabendige
semanticscholar   +1 more source