Results 91 to 100 of about 305,819 (266)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

New insights into the geology and ore genesis of the Aregijeh and Emarat Pb-Zn deposits, South Arak: Constraints from mineralogy, texture, and fluid inclusions [PDF]

علوم زمین خوارزمی
The Aregijeh and Emarat Pb-Zn deposits are hosted by clastic-carbonate sequences of the Early Cretaceous in south Arak. These deposits formed in the northern Sanandaj-Sirjan zone within an intracontinental rift setting.
Zahra Alaminia, Amir Salar Boroon, Meisam Tadayon   +2 more
doaj  

Influencing Factors of Hydrocarbon Migration and Adjustment at the Edge of a Stable Cratonic Basin: Implications from Fluid Inclusions, Quantitative Fluorescence Techniques, and Geochemical Tracing

Energies
Understanding the mechanisms of hydrocarbon migration, accumulation, and alteration, particularly how evolution controls these processes, is critical for exploring lithologic hydrocarbons in reservoirs. In the complex tectonic settings of the continental
Zhengqi Yang, Xin Cheng, Siqi Ouyang, Zhe Liu, Yuting Cheng, Shuqi Lan, Lei Xue, Ting Zhang, Yiqian Qu   +8 more
doaj   +1 more source

Central Europe temperature constrained by speleothem fluid inclusion water isotopes over the past 14,000 years. [PDF]

Sci Adv, 2019
Affolter S, Häuselmann A, Fleitmann D, Edwards RL, Cheng H, Leuenberger M.   +5 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Fluid inclusion petrology and microthermometry of the Cocos Ridge hydrothermal system, IODP Expedition 344 (CRISP 2), Site U1414. [PDF]

Geochem Geophys Geosyst, 2016
Brandstätter J, Kurz W, Krenn K, Micheuz P.   +3 more
europepmc   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source