Results 91 to 100 of about 4,332,918 (396)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Inclusion of a perfect fluid term into the Einstein-Hilbert action
, 2016 I introduce a method to obtain the stress-energy tensor of the perfect fluid by adding a suitable term to the Einstein-Hilbert action. Variation should be understood with respect to the metric.Comment: 8 pages.
Minguzzi, E.
core
Nonsingular black holes, wormholes, and de Sitter cores from anisotropic fluids
, 2017 We study Born-Infeld gravity coupled to an anisotropic fluid in a static, spherically symmetric background. The free function characterizing the fluid is selected on the following grounds: i) recovery of the Reissner-Nordstr\"om solution of GR at large ...
Menchon, C. +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Frontiers in Earth ScienceThe Chazangcuo copper-lead-zinc deposit (hereafter referred to as the Chazangcuo deposit) is situated in the northern portion of the western section of the Gangdese polymetallic metallogenic belt in Tibet, with ore bodies strictly governed by Linzizong ...
Yan Li +8 more
doaj +1 more source
Budding and Domain Shape Transformations in Mixed Lipid Films and Bilayer Membranes
, 2005 We study the stability and shapes of domains with spontaneous curvature in fluid films and membranes, embedded in a surrounding membrane with zero spontaneous curvature.
Harden, James L. +2 more
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Episodes of fissure formation in the Alps: connecting quartz fluid inclusion, fissure monazite age, and fissure orientation data. [PDF]
Swiss J Geosci, 2021 Gnos E +5 more
europepmc +1 more source