Results 101 to 110 of about 109,213 (331)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Endolithic colonization of fluid inclusion trails in mineral grains [PDF]

, 2005
Many scenarios for the colonization of planetary surfaces by microbial life involve endoliths.
Baron, M., Cockell, C. S., Parnell, J.
core  

Hydrocarbon Accumulation Periods in the Upper Paleozoic Strata of the Western Ordos Basin, China, Based on Fluid Inclusions and Basin Modeling. [PDF]

ACS Omega, 2023
Zhang F, Chen Z, Zhao Z, Gao J, Fu L, Li C, Zhang L.   +6 more
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Geological setting of silica in Dehnow-Abid region (Eshghabad northeast) using fluid inclusions studies

Journal of Economic Geology, 2017
Introduction Dehnow-Abid area is a part of the geological map of Eshghabad with scale 1:100000 (Aghanabati, 1994) that is located about 20 kilometers northeast of Eshghabad and in the coordinates of 57° 6´ 0" to 57° 10´ 0" eastern longitude and 34° 28 ...
Omid Yazdanpanah, Ali Akbar Hassannezhad
doaj   +1 more source

Characterization of Crude Oil, Formation Water, and Fluid Inclusions of Hydrocarbon-Bearing Strata and Their Hydrocarbon Geological Significance in the Wuliyasitai Southern Sub-sag of the Erlian Basin, China. [PDF]

ACS Omega, 2023
Si W, Hou D, Cao L.
europepmc   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Inclusions induced phase separation in mixed lipid film

, 1999
The effect of rigid inclusions on the phase behavior of a film containing a mixture of lipid molecules is investigated. In the proposed model, the inclusion-induced deformation of the film, and the resulting energy cost are strongly dependent upon the ...
Safran, S., Sens, P.
core   +3 more sources

Ingredients for microbial life preserved in 3.5 billion-year-old fluid inclusions. [PDF]

Nat Commun, 2021
Mißbach H, Duda JP, van den Kerkhof AM, Lüders V, Pack A, Reitner J, Thiel V.   +6 more
europepmc   +1 more source

A Final Word on Fluid Inclusions [PDF]

, 1903

openalex   +1 more source