Results 111 to 120 of about 117,004 (351)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Characteristics of Ore-forming Fluid and Mineralization of Jinqingding Gold Deposit in Mouru Metallogenic Belt, Jiaodong

open access: yesKuangchan zonghe liyong
The Mouru Gold Metallogenic Belt is one of the three major one in the Jiaodong Gold Metallogenic Zone. The Jinqingding Gold Deposit is located in the southern part of the metallogenic belt and is a large quartz vein-type gold one. The research on its ore-
Qian SONG   +5 more
doaj   +1 more source

Geological setting of silica in Dehnow-Abid region (Eshghabad northeast) using fluid inclusions studies

open access: yesJournal of Economic Geology, 2017
Introduction Dehnow-Abid area is a part of the geological map of Eshghabad with scale 1:100000 (Aghanabati, 1994) that is located about 20 kilometers northeast of Eshghabad and in the coordinates of 57° 6´ 0" to 57° 10´ 0" eastern longitude and 34° 28 ...
Omid Yazdanpanah, Ali Akbar Hassannezhad
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Fluid charging and hydrocarbon accumulation in the Cambrian Longwangmiao Formation of Moxi Structure, Sichuan Basin, SW China

open access: yesPetroleum Exploration and Development, 2018
: The multi-stage minerals filled in pore space were sequenced, and the charging stages of fluid and hydrocarbon were reconstructed based on the observation of drilling cores and thin sections, homogeneous temperature testing of fluid inclusions, Laser ...
Fanghao XU   +3 more
doaj   +1 more source

Fluid and Halide Melt Inclusions of Magmatic Origin in the Ultramafic and Lower Banded Series, Stillwater Complex, Montana, USA [PDF]

open access: yes, 2017
Fluid and melt inclusions trapped in igneous rocks below the platinum-group element (PGE)-rich J-M reef in the Stillwater Complex, Montana provide a physiochemical record of a continuum of high P-T magmatic-hydrothermal and low P-T metamorphic events ...
Bray, C. J.   +4 more
core  

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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