Results 71 to 80 of about 6,226,089 (293)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Universal Programmable Portable Measurement Device for Diagnostics and Monitoring of Industrial Fluid Power Systems. [PDF]

Sensors (Basel), 2021
Dindorf R, Wos P.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A portable fluid power simulation model library and its application

, 2006
The paper presents a fluid power model library in the equation-based modelling language Modelica and shortly shows how the library can be used in simulation software such as Matlab.
Larsson, Jonas,
core  

Structural Optimization of a High-Speed Press Considering Multi-Source Uncertainties Based on a New Heterogeneous TOPSIS

Applied Sciences, 2018
In order to achieve high punching precision, good operational reliability and low manufacturing cost, the structural optimization of a high-speed press in the presence of a set of available alternatives comprises a heterogeneous multiple-attribute ...
Jin Cheng, Yangyan Zhang, Yixiong Feng, Zhenyu Liu, Jianrong Tan   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Avoidance of Pressure Oscillations in Discrete Fluid Power Systems with Transmission Lines - An Analytical Approach

, 2014
Discrete fluid power technology attracts great attention because it enables energy efficiency and robust system architectures. However, the discrete nature of this technology naturally brings shifting phenomenons into the picture.
Pedersen, Henrik C.; id_orcid, Hansen, Anders Hedegaard; id_orcid   +1 more
core  

Motion planning for hyper-redundant manipulator systems: combining path following and improved APF-RRT* Path finding

Complex & Intelligent Systems
Hyper-redundant manipulator systems (HRMSs) have significant applications in various scenarios. Due to their excessive degrees of freedom (DOF), they can navigate into confined spaces and perform tasks such as exploration, detection, and maintenance ...
Hongcheng Ji, Cheng Wang, Chengzhen Wang, Haibo Xie   +3 more
doaj   +1 more source