Results 81 to 90 of about 6,226,089 (293)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Multi-Objective Optimization of VBHF in Deep Drawing Based on the Improved QO-Jaya Algorithm

Chinese Journal of Mechanical Engineering
Blank holder force (BHF) is a crucial parameter in deep drawing, having close relation with the forming quality of sheet metal. However, there are different BHFs maintaining the best forming effect in different stages of deep drawing.
Xiangyu Jiang, Zhaoxi Hong, Yixiong Feng, Jianrong Tan   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Investigation of flow-induced noise reduction in high-specific-speed centrifugal pumps using bionic blades

Scientific Reports
To reduce the flow-induced noise of centrifugal pumps and reveal the noise source characteristics inside the pumps, this paper designs a bionic blade based on the “tubercle effect” of humpback whales.
Yongxin Jin, Tao Cheng, Jie Fu, Guangtai Shi, Lei He   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Ohio Power Siting Board

, 2004
Title from PDF p. [1] (viewed on June 15, 2007).; "Created: 7/6/2004 ..."--Document properties screen.; Brochure. Intended to be printed off on 1 sheet, front and back, and folded in fourths horizontally.; Harvested from the web on 6/15 ...
Ohio Power Siting Board.
core  

A Physics-Guided Hybrid Network for Robust Hydrodynamic Parameter Identification of UUVs Under Lumped Disturbances

Journal of Marine Science and Engineering
Accurate identification of hydrodynamic parameters is essential for high-fidelity modeling and control of unmanned underwater vehicles (UUVs). Compared with towing tank experiments and computational fluid dynamics simulations, system identification based
Xinyu Fei, Lu Wang, Ruiheng Liu, Shipang Qian, Jiaxuan Song, Suohang Zhang, Yanhu Chen, Canjun Yang   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Active Lubrication for Reducing Wear and Vibration: A combination of Fluid Power Control and Tribology

, 2002
The use of fluid power to reduce and control rotor vibration in rotating machines is investigated. An active hybrid bearing is studied, whose main objective is to reduce wear and vibration between rotating and stationary machinery parts.
Santos, Ilmar, Nicoletti, Rodrigo
core  

Online Life Cycle Assessment for Fluid Power Manufacturing Systems – Challenges and Opportunities

, 2018
Part 2: Service Engineering Based on Smart Manufacturing CapabilitiesInternational audienceIncreasing demands for highly flexible production, e.g. mass customization, as well as the production industries’ search for new business models, enabled by big ...
Alt, Raphael, Rückert, Marcel, Merkelbach, Stephan, Schmitz, Katharina   +3 more
core   +1 more source