Results 101 to 110 of about 594,017 (304)

Evaluation of end-tidal carbon dioxide as a marker of fluid responsiveness in mechanically ventilated patients with shock: a prospective study in a tertiary care center in India

Monaldi Archives for Chest Disease
Shock management in intensive care unit (ICU) patients requires accurate assessment of fluid responsiveness to optimize outcomes. Dynamic indices, such as passive leg raising (PLR), are often underutilized due to invasive or complex techniques.
Ganesh Narwade, Shibdas Chakrabarti, Rajnish Kaushik, Rohit Kumar, Neeraj Gupta, Nitesh Gupta, Pranav Ish, Manu Madan, Mahendran AJ, Tanmaya Talukdar   +9 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Outcomes After Initial Rehydration with Isotonic Saline or Ringer’s Lactate in Pediatric Acute Gastroenteritis (1-59 Months): A Single-center Retrospective Cross-sectional Study

Haseki Tıp Bülteni
Aim: The optimal choice of initial intravenous crystalloid solution in pediatric acute gastroenteritis (AGE) remains a matter of clinical debate due to differing effects on acid–base status and overall recovery.
Ceren Yilmaz Donmez, Berker Okay, Halil Ugur Hatipoglu, Kamil Sahin   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A Prospective Observational Study to Compare Stroke Volume Variation with Pleth Variability Index in Predicting Fluid Responsiveness in Mechanically Ventilated Adult Patients Undergoing Major Abdominal Oncosurgery

Journal of Onco-Anaesthesiology and Perioperative Medicine
Background and Aims: Determining intravascular volume status is crucial to planning fluid therapy in major surgery. Stroke volume variation (SVV) and pleth variability index (PVI) are dynamic indicators of fluid responsiveness.
Suha Abdul Salam, Mary Thomas, Deepthi J. Prabhu   +2 more
doaj   +1 more source

Bacterial Yield from Quantitative Cultures of Bronchoalveolar Lavage Fluid in Patients with Pneumonia on Antimicrobial Therapy [PDF]

, 2012
Eun Sun Kim, Eui-Chong Kim, Sang‐Min Lee, Seok-Chul Yang, Chul‐Gyu Yoo, Young Whan Kim, Sung Koo Han, Jae‐Joon Yim   +7 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fluid Therapy in COVID-19 Disease: Review

, 2020
Nasrin Esfandiar, Farshid Kompani
openalex   +2 more sources

Surrogate Cerebrospinal Fluid Biomarkers for Assessing the Efficacy of Gene Therapy in Hurler Syndrome

, 2021
Reiner F. Haseloff, Stéphanie Trudel, Ramona Birke, Michael Schümann, Eberhard Krause, Cathy Gomila, Jean‐Michel Heard, Ingolf E. Blasig, Jérôme Ausseil   +8 more
openalex   +1 more source

Effects of Fluid Therapy on Mesenteric Microcirculation Using New Probe-Based Confocal Laser Endomicroscopy (Cellvizio®) in a Porcine Model of Endotoxic Shock [PDF]

, 2021
Charlotte Daniere, Guillaume Louart, Benjamin Louart, Marylène Bacle, Florian Bazalgette, Antonia Pérez‐Martin, Laurent Müller, Jean‐Yves Lefrant, Claire Roger   +8 more
openalex   +1 more source