Results 111 to 120 of about 1,007,541 (342)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]

, 2011
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Cai, Y, Cao, J, Long, Q, Lv, J, Xu, S, Yao, W, Zhou, Y   +6 more
core   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Fluidoterapia en Neurocirugía Craneal

Revista Electrónica de AnestesiaR, 1970
La fluidoterapia junto a la hipnosis, la protección neurovegetativa, el alivio del dolor y el mantenimiento de un adecuado bloqueo neuromuscular es uno de los pilares fundamentales de la práctica anestésica. Valorar las necesidades hídricas es un difícil
Helena Benito Naverac
doaj   +1 more source

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. [PDF]

, 2014
OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
A Babaev, A Bourgoin, A Combes, A Dubin, A Geppert, A Gestel van, A Perel, A Perel, A Rhodes, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, AE Jones, AF Connors Jr, Alexandre Mebazaa, AM Schulman, Andrew Rhodes, AP Wheeler, AS Beraud, B Bouhemad, B Lamia, B Vallet, BP Cholley, BR Soller, C Alberti, C Brun-Buisson, C Brun-Buisson, C Brun-Buisson, C Pierrakos, CA Polanczyk, Christoph Hofer, CI Pro, D Annane, D Atkins, D Backer De, D Backer De, D Backer De, D Backer De, D Backer De, D Fagnoul, D LeDoux, Daniel De Backer, DR Holmes Jr, E Kupersztych-Hagege, E Rivers, E Silva, EP Rivers, F Boissier, F Michard, F Michard, F Vallee, G Friedman, G Hernandez, G Lheritier, G Marecaux, G Tachon, GA Wanner, H Flaatten, H Zhang, H Zhang, HB Nguyen, HH Awad, I Jawad, I Salvo, I Werra de, J Bakker, J Bakker, J Creteur, J Maizel, J Mesquida, Jan Bakker, JB Hall, JD Ricard, Jean Louis Teboul, Jean Louis Vincent, JH McGowan, JJ Ronco, JL Teboul, JL Vanoverschelde, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JP Quenot, JP Revelly, K Bouferrache, L Jacquet, M Antonelli, M Cannesson, M Cecconi, M Cecconi, M Cecconi, M Feissel, M Howell, M Pinsky, MA Hayes, Massimo Antonelli, Maurizio Cecconi, ME Genderen van, ME Genderen van, ME Hands, ME Mikkelsen, MH Weil, MH Weil, MI Monge Garcia, MI Monge Garcia, Michael R. Pinsky, MR Pinsky, MR Shah, NJ Ekbal, O Godje, O Hamzaoui, O Taton, P Asfar, P Asfar, P Vignon, P Wacharasint, PE Marik, PT O’Gara, RA Linton, Richard Beale, RJ Goldberg, RJ Goldberg, Roman Jaeschke, RP Dellinger, RS Hotchkiss, S Harvey, S Heenen, S Magder, S Magder, S Magder, S Magder, S Marque, S Trzeciak, SA Stern, SD Murdoch, SF Nagueh, SG Sakka, SM Cain, SR Ommen, TC Jansen, TC Jansen, TC Jansen, TC Jansen, VS Edul, WH Bickell, WT Linde-Zwirble, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, Y Sakr, Y Sakr   +157 more
core   +4 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

CHANGES IN THE CEREBROSPINAL FLUID IN NEUROSYPHILIS AFTER MALARIA THERAPY [PDF]

, 1946
M. Whelen
openalex   +1 more source

Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. [PDF]

, 2016
BackgroundOne potential mechanism for early superficial cartilage wear in normal joints is alteration of the lubricant content and quality of synovial fluid.
Chen, Albert C, D'Lima, Darryl D, Hansen, Bradley C, Hasegawa, Akihiko, Koziol, Jim, Lotz, Martin K, Masuda, Koichi, Quach, Phu, Ren, Shuwen, Sah, Robert L, Temple-Wong, Michele M   +10 more
core   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion [PDF]

, 2013
Background: The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown.
A Kumar, A Peris, A Rhodes, Berthold Bein, Cordula M. Stover, D De Backer, D De Backer, D Osman, D Talmor, D Talmor, DA Reuter, E Azoulay, EE de Waal, F Michard, F Michard, G Dechman, J Graf, J Mayer, J Renner, J Renner, J Sagrista-Sauleda, Jan Schöttler, Jochen Renner, K Vaska, Katharina Heß, M Balik, M Cannesson, M Cannesson, M Hadian, Markus Steinfath, Matthias Gruenewald, MR Lopes, MR Pinsky, O Broch, O Nishida, Ole Broch, P Pelosi, Patrick Meybohm, PE Marik, R Jacob, R Pearse, RJ Trof, S Heenen, S Magder, S Rex, S Rex, SG Sakka, SH Loring   +47 more
core   +2 more sources