Results 51 to 60 of about 15,097 (295)

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34+ hematopoietic cells while allowing the detection of tumorigenic expansion

open access: yesFrontiers in Bioengineering and Biotechnology
Long-term culture of primary lymphocytes and hematopoietic stem and progenitor cells (HSPCs) is pivotal to their expansion and study. Furthermore, genetic engineering of the above-mentioned primary human cells has several safety needs, including the ...
Paolo Ritter   +16 more
doaj   +1 more source

Real-time Analysis of Electrolytes in Sweat Through a Wearable Sensing Platform

open access: yesProceedings, 2019
The field of biochemical sensing is evolving from the use of bulky apparatuses to the development of miniaturized systems allowing personal sensing and point of care analysis.
Paolo Pirovano   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On Dominant Oscillation Frequency of a Simplified Fluidic Oscillator

open access: yesJournal of Fluid Science and Technology, 2011
In the present study, we investigate a self-excited oscillatory phenomenon of a two-dimensional confined jet with a rectangular-cross-section cylinder as a downstream target.
Katsuya HIRATA   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Adipose tissue explant culture using PDMS flow chambers: an alternative to static explant culture

open access: yesAdipocyte
As obesity rates continue to rise, it is important that we can effectively study adipose tissue to understand its physiological contribution in individuals with obesity.
M Cohen   +11 more
doaj   +1 more source

Millimeter-Wave Chemical Sensor Using Substrate-Integrated-Waveguide Cavity

open access: yesSensors, 2016
This research proposes a substrate-integrated waveguide (SIW) cavity sensor to detect several chemicals using the millimeter-wave frequency range. The frequency response of the presented SIW sensor is switched by filling a very small quantity of chemical
Muhammad Usman Memon, Sungjoon Lim
doaj   +1 more source

Fluidic self-alignment applied to a micro-fluidic system

open access: yesIEICE Electronics Express, 2006
A technique for the self-alignment of components is applied to the assembly of a passive micro-valve which is to be used for safety purposes in a miniature fuel cell. The technique uses the capillary forces originating in the interactions of HMDS (Hexadimethyldisilazane) and the faces of the components to achieve their passive alignment. HMDS is chosen
Debray, Alexis   +3 more
openaire   +3 more sources

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