Results 61 to 70 of about 2,380,639 (287)

Throughput through thin-film fluidics

, 2008
We demonstrate fluidics realized in thin film plastic foils patterned using roll-to- roll nanoimprinting lithography (rrNIL). Realizing fluidics devices in thin plastic foils opens up for parallel operation in stacked devices.
Mäkelä, Tapio; id_orcid, Majander, Päivi, Tegenfeldt, Jonas, Beech, Jason   +3 more
core   +1 more source

Hollow Fiber Microreactor Combined with Digital Twin to Optimize the Antimicrobial Evaluation Process

Micromachines
In order to reproduce pharmacokinetics (PK) profiles seen in vivo, the Hollow Fiber Infection Model (HFIM) is a useful in vitro module in the evaluation of antimicrobial resistance.
Kazuhiro Noda, Toshihiro Kasama, Marie Shinohara, Masakaze Hamada, Yukiko T. Matsunaga, Madoka Takai, Yoshikazu Ishii, Ryo Miyake   +7 more
doaj   +1 more source

Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism

eLife, 2021
Oxygen (O2) and other dissolved gases such as the gasotransmitters H2S, CO, and NO affect cell metabolism and function. To evaluate effects of dissolved gases on processes in tissue, we developed a fluidics system that controls dissolved gases while ...
Varun Kamat, Brian M Robbings, Seung-Ryoung Jung, John Kelly, James B Hurley, Kenneth P Bube, Ian R Sweet   +6 more
doaj   +1 more source

Fluidics of Single and Double Blade Guillotine Vitrectomy Probes in Balanced Salt Solution and Artificial Vitreous

Translational Vision Science & Technology, 2018
Purpose To assess the fluidics of double-vitreous cutter blade (DB) compared with single-blade (SB) guillotine with 23-, 25-, and 27-gauge vitrectomy probes. To assess flow characteristics and flow rates in viscous and viscoelastic fluids.
M. Romano, A. Stocchino, Mariantonia Ferrara, A. Lagazzo, R. Repetto   +4 more
semanticscholar   +1 more source

New Drop Fluidics Enabled by Magnetic-Field-Mediated Elastocapillary Transduction. [PDF]

Langmuir, 2016
This research introduces a new drop fluidics that uses a deformable and stretchable elastomeric film as the platform instead of the commonly used rigid supports.
Saheli Biswas, Y. Pomeau, Manoj K. Chaudhury   +2 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34+ hematopoietic cells while allowing the detection of tumorigenic expansion

Frontiers in Bioengineering and Biotechnology
Long-term culture of primary lymphocytes and hematopoietic stem and progenitor cells (HSPCs) is pivotal to their expansion and study. Furthermore, genetic engineering of the above-mentioned primary human cells has several safety needs, including the ...
Paolo Ritter, Paolo Ritter, Stefania Oliveto, Stefania Oliveto, Chiara Cordiglieri, Alessandra Fasciani, Christian Andrea Di Buduo, Lucrezia della Volpe, Alberto Bocconi, Claudio Conci, Carolina Paula Miguel, Raffaella Di Micco, Raffaella Di Micco, Alessandra Balduini, Manuela Teresa Raimondi, Stefano Biffo, Stefano Biffo   +16 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Automated Stopped-Flow Fluorimetric Sensor for Biologically Active Adamantane Derivatives Based on Zone Fluidics

Molecules, 2019
A zone-fluidics (ZF) based automated fluorimetric sensor for the determination of pharmaceutically active adamantine derivatives, i.e., amantadine (AMA), memantine (MEM) and rimantadine (RIM) is reported.
P. Tzanavaras, S. Papadimitriou, C. Zacharis   +2 more
semanticscholar   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source