Results 81 to 90 of about 13,369 (194)

GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus [PDF]

, 2000
We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric acid, type A (GABAA) receptor (α1, α2, α3, α5, β2, β3, γ2S, and γ2L) and all four subunits of the α-amino-3-hydroxy-5-methylsoxazole ...
Araujo, Francisco, Bergis, Olivier, Revilla Torres, María Elisa, Ruano Caballero, Diego, Vela, Jose, Vitorica Ferrández, Francisco Javier   +5 more
core  

Zolpidem restores sleep and decreases amyloid in a mouse model

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Deficits in non–rapid eye movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing gamma‐aminobutyric acid‐ergic (GABAergic) signaling can restore sleep. Unbiased computational analysis identified zolpidem as high‐affinity GABA receptor modulator facilitating chloride transport that could slow AD.
Lu Yu, Shinya Yokomizo, Tri H. Doan, Qiuchen Zhao, Akshatha Ganne, Meenakshisundaram Balasubramaniam, Ksenia V. Kastanenka   +6 more
wiley   +1 more source

Selective inhibition of extra-synaptic α5-GABA_A receptors by S44819, a new therapeutic agent [PDF]

, 2017
In the mammalian central nervous system (CNS) GABAA receptors (GABAARs) mediate neuronal inhibition and are important therapeutic targets. GABAARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression of 20-30 GABAAR subtypes.
Adam R. Brown, Adrienn Pálvölgyi, Atack, Balázs Mihalik, Barker, Belelli, Ben G. Gunn, Bergmann, Bolognani, Bonin, Botta, Brown, Brown, Brown, Capogna, Caraiscos, Clarkson, Cobb, Darmani, Delia Belelli, Drexel, Ferenc A. Antoni, Fisahn, Fritschy, Gacsályi, Gacsályi, Hausrat, Herd, Herd, Huerta, István Gacsályi, István Ling, Jeremy J. Lambert, Jones, József Barkóczy, Karayannis, Katalin Pallagi, Keene, Kinnavane, Knust, Lake, Lerma, Ling, Ling, Lori-An Etherington, Lüddens, Maconochie, Martin, Matthew R. Livesey, Mendez, Michael Spedding, Mihalik, Milic, Neves, Olivia Monteiro, Olsen, Peden, Pirker, Prenosil, Péter Varga, Redrobe, Rudolph, Salesse, Salmon, Serwanski, Szabolcs Kertész, Thompson, Ueno, Wang, Wisden, Wlodarczyk, Wu, Zarnowska, Zhang, Zurek   +74 more
core   +2 more sources

Remimazolam-flumazenil provides fast recovery from general anesthesia compared to propofol during radiofrequency catheter ablation of atrial fibrillation

Scientific Reports
The optimal anesthetic agent for radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) and its impact on the recovery profiles remain uncertain.
Seohee Lee, Jaemoon Lee, So Yeong Hwang, Jae-Woo Ju, Karam Nam, Hyo-Jeong Ahn, So-Ryoung Lee, Eue-Keun Choi, Yunseok Jeon, Youn Joung Cho   +9 more
doaj   +1 more source

Imaging Neuroinflammation – from Bench to Bedside [PDF]

, 2015
Neuroinflammation plays a central role in a variety of neurological diseases, including stroke, multiple sclerosis, Alzheimer’s disease, and malignant CNS neoplasms, among many other.
Chen, John W, Pulli, Benjamin
core   +1 more source

Analgesic Effect of Safranal in Animal Model of Acute Pain; Possible role of the GABAergic Pathway

مجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: There are reports for analgesic, anti-inflammatory, hypnotic, neuroprotective and anti-oxidative effects of safranal. The aim of this study was to investigate the analgesic effects of safranal using acute pain method in rat and ...
Esmael Izadpanah, Elham Saei, Omid Abdollahi, Abbas Ahmadi, Mohammad Raman Moloudi   +4 more
doaj  

Case report of atypical re-sedation after general anesthesia using remimazolam [PDF]

Anesthesia and Pain Medicine
Background Remimazolam, an ultra-short-acting anesthetic with flumazenil as a reversal agent, typically facilitates patient awakening postoperatively. However, our case reveals an unusual occurrence: despite flumazenil initially restoring consciousness ...
Soo Jee Lee, Insik Jung, Seongmin Park, Seunghee Ki   +3 more
doaj   +1 more source

The Severity of Ischemia Determines and Predicts Malignant Brain Edema in Patients with Large Middle Cerebral Artery Infarction [PDF]

, 2011
In order to determine the impact of the severity of ischemia on malignant edema formation, we investigated various degrees of perfusional deficit by (11)C-flumazenil PET in patients with large middle cerebral artery (MCA) infarction.17 patients with ...
Bosche, B., Dohmen, C., Galldiks, N., Graf, R., Kracht, L.   +4 more
core   +1 more source

Age-Related Response to Remimazolam among Older Patients Undergoing Orthopedic Surgery: A Single-Center Prospective Observational Study

Medicina
Background and Objectives: Remimazolam, an ultra-short-acting benzodiazepine, is increasingly used in procedural sedation and general anesthesia. It is characterized by rapid onset of action, inactive metabolites, no delay in recovery, and few adverse ...
Min Suk Chae, Nuri Lee, Hyun Jung Koh
doaj   +1 more source

In Vivo Measurement of Hippocampal GABAA/cBZR Density with [18F]-Flumazenil PET for the Study of Disease Progression in an Animal Model of Temporal Lobe Epilepsy [PDF]

, 2014
PURPOSE: Imbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE).
Berard, A, Binns, David S, Bouilleret, V, Dedeurwaerdere, S, Gregoire, MC, Hicks, RJ, Katsifis, A, Myers, Damian, O'Brien, TJ, Roselt, P, Vivash, L, Wimberley, C   +11 more
core   +2 more sources