Results 241 to 250 of about 3,257,031 (299)

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

Advanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu, I‐Ju Liu, Hsiang‐Yun Chih, Tsai‐Ching Hsu, Ju‐An Liang, Chia‐Wei Kuo, Bor‐Show Tzang, Wen‐Hsuan Chiang   +7 more
wiley   +1 more source

LUCas: Light-Uncaged Cas13a using photocleavable interfering guide RNAs. [PDF]

Nucleic Acids Res
Ng CF, Krishnamurthy D, Dextre A, Chorlay A, Ott M, Fletcher DA.   +5 more
europepmc   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Reliability of Point-of-Care Vitamin D Testing for Use in Primary Health Care: A Comparative Evaluation with Established CLIA Platforms. [PDF]

Int J Gen Med
Younes S, AlHamad T, Al-Louzi A, Al Khanji F, Ibrahim RM, Yaseen D, Al-Ansari R, Eltaweel A, Trad F, Nizamuddin PB, Zein N, Younes N, El Chaar D, Tang P, Al-Dewik N, Abu-Raddad LJ, Nasrallah GK.   +16 more
europepmc   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Design, Synthesis, and In Vitro Evaluation of a PSMA-Targeted Doxorubicin Conjugate. [PDF]

ChemMedChem
Kumar S, Tyagi M, Pal R, Patro BS, Goswami D.   +4 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

ABHD2 activity is not required for the non-genomic action of progesterone on human sperm. [PDF]

Hum Reprod
Edwards M, Amaral A, Carter EM, Arnolds O, Vester K, Thrun A, Wigren E, Homan E, Ribera P, Bentley K, Haraldsson M, Theo-Emegano N, Loppnau P, Szewczyk MM, Cao MA, Barsyte-Lovejoy D, Dittmar N, Hans A, Weber M, Münchow J, Zhu WF, Temme L, Brenker C, Strünker T, Sundström M, Todd MH, Edwards AM, Lesche R, Gileadi O, Tredup C.   +29 more
europepmc   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

A Dual-Mode Nanozyme Assay Based on Photoactivated Mn-Doped Carbon Nanosheets for Rapid Evaluation of Antioxidant Responses in Tea Beverages and Dairy Tea Matrices. [PDF]

Foods
Lu Q, He Q, Fang X, Wei Z, Zhang Q, Song Y, Li S, Wang S.   +7 more
europepmc   +1 more source