Results 191 to 200 of about 283,742 (346)

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Enhanced Precision of Fluorescence In Situ Hybridization (FISH) Analysis Using Neural Network-Based Nuclear Segmentation for Digital Microscopy Samples. [PDF]

Sensors (Basel)
Csizmadia A, Molnar B, Kucarov MD, Koos K, Paulik R, Kapczar D, Krenacs L, Csernus B, Papp G, Krenacs T.   +9 more
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Fluorescence In Situ Hybridization on Sperm Using Alkaline Denaturation

BioTechniques, 2002
L.J. Aridgides, M. Stacey, L. Brihn, D. Scott, C. Osgood   +4 more
doaj   +1 more source

Beyond diagnosis: exploring the extended clinical utility of urine fluorescence in situ hybridization in upper tract urothelial carcinoma. [PDF]

BMC Urol
Zhao Y, Zhang N, Zhang S, Zhang X, Liu L, Chen J.   +5 more
europepmc   +1 more source

Analysis of chromosomes in molecular tumor and radiation cytogenetics: Approaches, apllications, perspectives [PDF]

, 1992
Cremer, Christoph, Cremer, Thomas
core  

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Protocol for multiplex whole-mount RNA fluorescence in situ hybridization combined with immunohistochemistry in the mosquito brain. [PDF]

STAR Protoc
Suppermpool A, Trivedi C, Powell GT, Andrés M.   +3 more
europepmc   +1 more source

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

Proceedings of the National Academy of Sciences of the United States of America, 1988
D. Pinkel, J. Landegent, Colin Collins, J. Fuscoe, R. Segraves, J. Lucas, J. Gray   +6 more
semanticscholar   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source