Resilient Biophysical Phenotype of Memory CD4 + T Cells in Long‐Lived Mice
Aging is associated with increased stiffness and reduced migratory capacity of memory CD4+ T cells; however, these biophysical declines do not persist in exceptionally long‐lived mice. Instead, long‐lived individuals preserve T cell mechanics, migration and intracellular architecture, supporting mechanical resilience as a hallmark of successful immune ...
Aldo Abarca‐Ortega +6 more
wiley +1 more source
Size of Biomolecular Condensates Dictates Fate in Liquid-Solid Phase Transitions through Amorphous-Amyloid Competition. [PDF]
Kawakami J +20 more
europepmc +1 more source
Running an electron microscopy core facility
Abstract As electron microscopes became more costly, technically complex, and integral to a wide range of scientific fields, centralised electron microscopy (EM) core facilities have become essential for maintaining accessibility, performance, and quality.
Ilkka Miinalainen, Eija Jokitalo
wiley +1 more source
A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. [PDF]
Odell J, Nedza K, Lammerding J.
europepmc +1 more source
Abstract Biomedical imaging is increasingly defined by a paradox: advances in microscopy now enable the routine generation of extraordinarily rich, high‐dimensional datasets, yet the extraction of reproducible, biologically meaningful insight from those data often remains a major bottleneck.
Yasmin M. Kassim, Uri Manor
wiley +1 more source
Acidosis Regulates Microtubule Dynamics via the β1 Integrin/RhoA/CRMP-2 Axis. [PDF]
Lachowski D +8 more
europepmc +1 more source
Development of the HTRF assay to evaluate the auxin‐induced binding between TIR1 and IAA7
Summary Auxin plays diverse roles in plant growth and development, including sensing environmental changes. Quantifying the interaction between auxin coreceptors provides the molecular basis for cells to sense and adapt to environmental cues. Although several assays are available, a more high‐throughput method is necessary to efficiently evaluate the ...
Jekson Robertlee, Shinya Hagihara
wiley +1 more source
RPA-ssDNA co-phase separation facilitates RAD51 enrichment during homologous recombination. [PDF]
Li Y +13 more
europepmc +1 more source
The Nuclear Transporter Transportin-3 Functions Under Oxidative Stress. [PDF]
Barling MAL +3 more
europepmc +1 more source
All-optical strategies to minimize photobleaching in reversibly switchable fluorescent proteins. [PDF]
Marín-Aguilera G +8 more
europepmc +1 more source

