Results 51 to 60 of about 1,989,764 (203)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Feedback Tracking and Correlation Spectroscopy of Fluorescent Nanoparticles and Biomolecules [PDF]

, 2008
The best way to study dynamic fluctuations in single molecules or nanoparticles is to look at only one particle at a time, and to look for as long as possible.
McHale, Kevin L.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Scaling spectroscopic approaches – from leaf albedo to ecosystems mapping [PDF]

, 2010
Field based spectroscopy for ecological and environmental monitoring has become an indispensable part of complete observational systems as defined in GEOSS (Global Earth Observation System of Systems).
Malenovský, Z, Bartholomeus, H, Schaepman, M.E., Malenovsky, Z., Schaepman-Strub, G, Schaepman, Michael E; https://orcid.org/, Bartholomeus, H., Hueni, A., Schaepman-Strub, G., Kneubühler, M; https://orcid.org/, Damm, A; https://orcid.org/, Kneubühler, M., Damm, A.   +12 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

A versatile standard for bathochromic fluorescence based on intramolecular FRET. [PDF]

, 2011
A perylene and a terrylene tetracarboxylic bisimide dyad was prepared in which an efficient energy transfer from the former to the latter is observed. The absorption spectrum of this compound covers a broad range.
Rosenbaum, Erik, A Andreas Walter, Lennart B.-Å. Johansson, Rosenbaum, Erik,, Andreas Walter, Walter, Andreas, A Erik Rosenbaumb, Johansson, Lennart B.-A., Erik Rosenbaum, Heinz Langhals, Johansson, Lennart B-Å,, Langhals, Heinz, Lennart B. -å. Johanssonb   +12 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Optimisation of wavelength modulated Raman spectroscopy : towards high throughput cell screening [PDF]

, 2013
In the field of biomedicine, Raman spectroscopy is a powerful technique to discriminate between normal and cancerous cells. However the strong background signal from the sample and the instrumentation affects the efficiency of this discrimination ...
Andrew Riches, C Simon Herrington, Robert F Marchington, Dholakia, Kishan, Marchington Robert F., Kishan Dholakia, Herrington, C. Simon, Marchington, Robert F., Riches Andrew, Riches, Andrew, Herrington C. Simon, Michael Mazilu, Praveen Bavishna B., Mazilu Michael, Mazilu, Michael, Dholakia Kishan, Bavishna B Praveen, Praveen, Bavishna B.   +17 more
core   +2 more sources