Results 61 to 70 of about 3,191,368 (342)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

First Design of a Contact Lens for Diagnosis of Dehydration

Biosensors
Dehydration is a serious medical problem for elderly patients and young children. The most widely used diagnostics are measurements of sodium ion (Na+) and potassium ion (K+) in blood serum.
Kundan Sivashanmugan, Reece E. Albert, Joseph R. Lakowicz   +2 more
doaj   +1 more source

Application of Curve Fitting and Radial Basis Function in the Quantitative Analysis of Molecular Fluorescence Spectroscopy

Chemical Engineering Transactions, 2018
The fluorescence of Lactobacillus plantarum solution was characterized by two-dimensional fluorescence spectroscopy and three-dimensional fluorescence spectroscopy and the quantitative detection of the fluorescence peak intensity of Lactobacillus ...
Huan Guo
doaj   +1 more source

Surface Plasmon Resonance Sensors on Raman and Fluorescence Spectroscopy

Italian National Conference on Sensors, 2017
The performance of chemical reactions has been enhanced immensely with surface plasmon resonance (SPR)-based sensors. In this review, the principle and application of SPR sensors are introduced and summarized thoroughly. We introduce the mechanism of the
Jiangcai Wang, Weihua Lin, En Cao, Xuefeng Xu, W. Liang, Xiaofang Zhang   +5 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Xanthines Studied via Femtosecond Fluorescence Spectroscopy

Molecules, 2016
Xanthines represent a wide class of compounds closely related to the DNA bases adenine and guanine. Ubiquitous in the human body, they are capable of replacing natural bases in double helices and give rise to four-stranded structures. Although the use of
Pascale Changenet-Barret, Lajos Kovács, Dimitra Markovitsi, Thomas Gustavsson   +3 more
doaj   +1 more source

Assessment of drinking water quality at the tap using fluorescence spectroscopy.

Water Research, 2017
Treated drinking water may become contaminated while travelling in the distribution system on the way to consumers. Elevated dissolved organic matter (DOM) at the tap relative to the water leaving the treatment plant is a potential indicator of ...
M. Heibati, C. Stedmon, Karolina Stenroth, S. Rauch, J. Toljander, M. Säve-Söderbergh, K. Murphy   +6 more
semanticscholar   +1 more source

Detection strategies for bioassays based on liquid chromatography, fluorescence spectroscopy and mass spectrometry [PDF]

, 2005
New detection strategies for bioassays based on liquid chromatography,\ud fluorescence spectroscopy and mass spectrometry were developed and are\ud presented within this ...
Hempen, Christel Maria
core   +1 more source

Protein-mediated dethreading of a biotin-functionalised pseudorotaxane [PDF]

, 2014
In this article, we describe the synthesis of new biotin-functionalised naphthalene derivatives 3 and 4 and their complexation behaviour with avidin and neutravidin using a range of analytical techniques.
Caldwell, S.T., Cooke, G., Cooper, A., Fitzpatrick, B., Khaled, B., Maclean, C., Nutley, M., Rabani, G., Riehle, M., Rotello, V.M., Smith, B.O., Woisel, P.   +11 more
core   +3 more sources