Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
SEROEPIDEMIOLOGICAL STUDY OF P. VIVAX MALARIA WITH SUSPECTED LONG INCUBATION IN IRAN [PDF]
P. vivax malaria with suspected long incubation have been frequently observed mostly in the northwest part of Iran in the course of Malaria Control and Malaria Eradication Operations.
Gh. H. Edrissian +2 more
doaj +1 more source
The prevalence of Toxoplasma infection in hospitalized patients in selected hospitals of Kerman. [PDF]
Toxoplasmosis is a disease caused by a ubiquitous,obilgate intrace;;ular protozoan"Toxoplasma gondii".the present study was undertaken to determine the prevalence of Toxoplasma infection in Kerman province of Iran.Atotal of 690 bllod samples,collected ...
H Keshavarz, S Mamishi, H Daneshvar
doaj
A comparative study on detection of bartonella henselae infection by culture followed by pcr, nested-pcr and ifa [PDF]
Cats are the main reservoirs of zoonotic Bartonella henselae which are the causative agents of Cat Scratch Disease (CSD). The aim of this study is to compare three diagnostic methods including culture followed by PCR from whole blood, nested-PCR from ...
DIREN SIGIRCI B +9 more
doaj +1 more source
A method for nucleic acid hybridization to isolated chromosomes in suspension [PDF]
A procedure was developed to provide differential fluorescent staining of metaphase chromosomes in suspension following nucleic acid hybridization. For this purpose metaphase chromosomes were isolated from a Chinese hamster x human hybrid cell line ...
Bier, Frank +5 more
core +1 more source
Evaluation of Two Types of Infectious Mononucleosis Antigen Slides by the Indirect Fluorescent-Antibody Technique [PDF]
The efficiency of two types of antigen slides was compared by using the indirect fluorescent-antibody technique. Fifty sera from infectious mononucleosis patients were tested concurrently on the two sets of slides for antibody to Epstein-Barr virus. The indirect fluorescent-antibody serum titer readings from the epoxy slides were either equal to or ...
L A, Dye, P M, Feorino
openaire +2 more sources
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Occurrence of hemorrhagic fever with renal syndrome in military unit stationed in the combat zone [PDF]
Since it has been recognized as a separate disease during the Korean war hemorrhagic fever with renal syndrome (HFRS) has often been discovered among the members of different armies in various countries, military personnel being the highest risk group ...
Ćirić Slaviša +5 more
doaj +1 more source
The scope of this paper is to illustrate the need for an improved quality assurance in fluorometry. For this purpose, instrumental sources of error and their influences on the reliability and comparability of fluorescence data are highlighted for ...
Ebert, P. +7 more
core +2 more sources
Indirect fluorescent-antibody technique for serological diagnosis of La Crosse (California) virus infections [PDF]
A clinically relevant indirect fluorescent-antibody technique (IFA) was developed for the serological diagnosis of La Crosse virus infections. The IFA (67%) was as sensitive as the hemagglutination inhibition (58%) and neutralization (58%) tests in the detection of antibodies in acute-phase specimens.
B J, Beaty +6 more
openaire +2 more sources

