Results 31 to 40 of about 36,085 (261)

Evaluation of the Indirect Fluorescent-Antibody Technique for Identification of Naegleria Species

Applied Microbiology, 1974
The indirect fluorescent-antibody technique was used to assess a rapid method for identification of amoebae belonging to the genus Naegleria . Thirty-eight Naegleria and eight other limax amoeba strains were examined by using one N ...
J, De Jonckheere, P, Van Dijck, H, Van de Voorde   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Neospora caninum in free-range chickens (Gallus gallus domesticus) from southern Brazil

Revista Brasileira de Parasitologia Veterinária, 2020
Neospora caninum is an obligate intracellular parasite that can infect many domestic and wild animals, including birds. These animals are important sources for monitoring of environmental contamination, as they could become infected through sporulated ...
João Pedro Sasse, Ana Clécia dos Santos Silva, Priscilla Gomes Carneiro, Beatriz de Souza Lima Nino, Fernando Emmanuel Gonçalves Vieira, Luiz Daniel de Barros, João Luis Garcia   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Comparative studies on anti-avian sera conjugated with fluorescin isothiocyanate [PDF]

Journal of Veterinary Medical Research, 2010
Rabbit antisera were successfully prepared against chickens; turkey; ducks; geese; pigeons and quails as antispecies and conjugated with fluorescein isothiocyanate (FITC).
M. H. Khodeir, Ghada M. El-Sadek, Elham A. El-Ibiary   +2 more
doaj   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Antibody elution with 2-me/SDS solution: Uses for multi-layer immunohistochemical analysis of wholemount preparations of human colonic myenteric plexus

Heliyon
Indirect immunofluorescence is usually restricted to 3-5 markers per preparation, limiting analysis of coexistence. A solution containing 2-mercaptoethanol and sodium dodecyl sulfate (2-ME/SDS) can elute indirect immunofluorescence labelling (i.e ...
Adam Humenick, M.E. Johnson, B.N. Chen, M. Wee, D.A. Wattchow, M. Costa, P.G. Dinning, S.J.H. Brookes   +7 more
doaj   +1 more source

Toxoplasma gondii Antigenuria in Patients with Acquired Immune Deficiency Syndrome

Memorias do Instituto Oswaldo Cruz, 1997
A longitudinal study was performed with sera and urine of patients with acquired immune deficiency syndrome (AIDS), taken before, during and after clinically Toxoplasma infection. The tested patients were followed for an average of two years.
Alberto Fachado, Lisset Fonseca, Luis Fonte, Esteban Alberti, Raymundo Cox, Frank Bandera   +5 more
doaj   +1 more source

CLINICO-DIAGNOSTIC STUDY ON BOVINE VIRAL DIARRHEA (BVD) IN SHEEP [PDF]

Veterinary Medical Journal - Giza, 2011
A private farm at Giza governorate of three hundred sheep was subjected for virological, immuno florescent, immune cytochemical and histopathological examinations. In this farm three sheep were dead (1% mortality) and forty animals (13% morbidity) showed
Amal Raof, M Dardiri, Mohamed Refaat
doaj   +1 more source